Clinical Presentation and Angiographic Characteristics of Saphenous Vein Graft Failure After Stenting. Insights From the SOS (Stenting Of Saphenous Vein Grafts) Trial

Christopher Lichtenwalter, James A de Lemos, Michele Roesle, Owen Obel, Elizabeth M. Holper, Donald Haagen, Bilal Saeed, Jose Miguel Iturbe, Kendrick Shunk, Joseph K. Bissett, Rajesh Sachdeva, Vassilios V. Voudris, Panagiotis Karyofillis, Biswajit Kar, James Rossen, Panayotis Fasseas, Peter Berger, Subhash Banerjee, Emmanouil S Brilakis

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Abstract

Objectives: We sought to compare the clinical presentation and angiographic patterns of saphenous vein graft (SVG) failure after stenting with a paclitaxel-eluting stent (PES) versus a similar bare-metal stent (BMS). Background: The mode of SVG failure after stenting has been poorly characterized. Methods: The SOS (Stenting Of Saphenous Vein Grafts) trial enrolled 80 patients with 112 lesions in 88 SVGs who were randomized to a BMS or PES. Angiographic follow-up at 12 months was available in 83% of the patients. Results: Binary angiographic restenosis occurred in 51% (24 of 47) of BMS-treated lesions versus 9% (4 of 43) of PES-treated lesions (p < 0.0001). Graft occlusion occurred in 9 of the 21 SVGs (43%) that failed in the BMS group and in 2 of 4 SVGs (50%) that failed in the PES group. SVG failure after stenting presented as an acute coronary syndrome in 10 of the 24 patients (42%) (7 of those 10 patients presented with non-ST-segment elevation acute myocardial infarction), stable angina in 9 (37%) patients, and without symptoms in 5 (21%) patients. Of the 19 patients (with 20 grafts) who developed symptomatic graft failure, repeat SVG revascularization was successfully performed in all 13 (100%) subtotally obstructed SVGs but was attempted (and successful) in only 1 of 7 (14%) occluded SVGs. Revascularization of a native coronary artery was performed in an additional 4 of 7 (57%) symptomatic patients with an occluded SVG. Conclusions: SVG failure after stenting often presents as acute myocardial infarction and with SVG occlusion. Compared with BMS, PES reduce SVG failure.

Original languageEnglish (US)
Pages (from-to)855-860
Number of pages6
JournalJACC: Cardiovascular Interventions
Volume2
Issue number9
DOIs
StatePublished - Sep 2009

Fingerprint

Saphenous Vein
Stents
Transplants
Paclitaxel
Metals
Myocardial Infarction
Stable Angina
Acute Coronary Syndrome
Coronary Vessels

Keywords

  • bare-metal stents
  • coronary artery bypass graft surgery
  • drug-eluting stents
  • outcomes
  • percutaneous coronary intervention
  • saphenous vein grafts

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Clinical Presentation and Angiographic Characteristics of Saphenous Vein Graft Failure After Stenting. Insights From the SOS (Stenting Of Saphenous Vein Grafts) Trial. / Lichtenwalter, Christopher; de Lemos, James A; Roesle, Michele; Obel, Owen; Holper, Elizabeth M.; Haagen, Donald; Saeed, Bilal; Iturbe, Jose Miguel; Shunk, Kendrick; Bissett, Joseph K.; Sachdeva, Rajesh; Voudris, Vassilios V.; Karyofillis, Panagiotis; Kar, Biswajit; Rossen, James; Fasseas, Panayotis; Berger, Peter; Banerjee, Subhash; Brilakis, Emmanouil S.

In: JACC: Cardiovascular Interventions, Vol. 2, No. 9, 09.2009, p. 855-860.

Research output: Contribution to journalArticle

Lichtenwalter, C, de Lemos, JA, Roesle, M, Obel, O, Holper, EM, Haagen, D, Saeed, B, Iturbe, JM, Shunk, K, Bissett, JK, Sachdeva, R, Voudris, VV, Karyofillis, P, Kar, B, Rossen, J, Fasseas, P, Berger, P, Banerjee, S & Brilakis, ES 2009, 'Clinical Presentation and Angiographic Characteristics of Saphenous Vein Graft Failure After Stenting. Insights From the SOS (Stenting Of Saphenous Vein Grafts) Trial', JACC: Cardiovascular Interventions, vol. 2, no. 9, pp. 855-860. https://doi.org/10.1016/j.jcin.2009.06.014
Lichtenwalter, Christopher ; de Lemos, James A ; Roesle, Michele ; Obel, Owen ; Holper, Elizabeth M. ; Haagen, Donald ; Saeed, Bilal ; Iturbe, Jose Miguel ; Shunk, Kendrick ; Bissett, Joseph K. ; Sachdeva, Rajesh ; Voudris, Vassilios V. ; Karyofillis, Panagiotis ; Kar, Biswajit ; Rossen, James ; Fasseas, Panayotis ; Berger, Peter ; Banerjee, Subhash ; Brilakis, Emmanouil S. / Clinical Presentation and Angiographic Characteristics of Saphenous Vein Graft Failure After Stenting. Insights From the SOS (Stenting Of Saphenous Vein Grafts) Trial. In: JACC: Cardiovascular Interventions. 2009 ; Vol. 2, No. 9. pp. 855-860.
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abstract = "Objectives: We sought to compare the clinical presentation and angiographic patterns of saphenous vein graft (SVG) failure after stenting with a paclitaxel-eluting stent (PES) versus a similar bare-metal stent (BMS). Background: The mode of SVG failure after stenting has been poorly characterized. Methods: The SOS (Stenting Of Saphenous Vein Grafts) trial enrolled 80 patients with 112 lesions in 88 SVGs who were randomized to a BMS or PES. Angiographic follow-up at 12 months was available in 83{\%} of the patients. Results: Binary angiographic restenosis occurred in 51{\%} (24 of 47) of BMS-treated lesions versus 9{\%} (4 of 43) of PES-treated lesions (p < 0.0001). Graft occlusion occurred in 9 of the 21 SVGs (43{\%}) that failed in the BMS group and in 2 of 4 SVGs (50{\%}) that failed in the PES group. SVG failure after stenting presented as an acute coronary syndrome in 10 of the 24 patients (42{\%}) (7 of those 10 patients presented with non-ST-segment elevation acute myocardial infarction), stable angina in 9 (37{\%}) patients, and without symptoms in 5 (21{\%}) patients. Of the 19 patients (with 20 grafts) who developed symptomatic graft failure, repeat SVG revascularization was successfully performed in all 13 (100{\%}) subtotally obstructed SVGs but was attempted (and successful) in only 1 of 7 (14{\%}) occluded SVGs. Revascularization of a native coronary artery was performed in an additional 4 of 7 (57{\%}) symptomatic patients with an occluded SVG. Conclusions: SVG failure after stenting often presents as acute myocardial infarction and with SVG occlusion. Compared with BMS, PES reduce SVG failure.",
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AU - Lichtenwalter, Christopher

AU - de Lemos, James A

AU - Roesle, Michele

AU - Obel, Owen

AU - Holper, Elizabeth M.

AU - Haagen, Donald

AU - Saeed, Bilal

AU - Iturbe, Jose Miguel

AU - Shunk, Kendrick

AU - Bissett, Joseph K.

AU - Sachdeva, Rajesh

AU - Voudris, Vassilios V.

AU - Karyofillis, Panagiotis

AU - Kar, Biswajit

AU - Rossen, James

AU - Fasseas, Panayotis

AU - Berger, Peter

AU - Banerjee, Subhash

AU - Brilakis, Emmanouil S

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N2 - Objectives: We sought to compare the clinical presentation and angiographic patterns of saphenous vein graft (SVG) failure after stenting with a paclitaxel-eluting stent (PES) versus a similar bare-metal stent (BMS). Background: The mode of SVG failure after stenting has been poorly characterized. Methods: The SOS (Stenting Of Saphenous Vein Grafts) trial enrolled 80 patients with 112 lesions in 88 SVGs who were randomized to a BMS or PES. Angiographic follow-up at 12 months was available in 83% of the patients. Results: Binary angiographic restenosis occurred in 51% (24 of 47) of BMS-treated lesions versus 9% (4 of 43) of PES-treated lesions (p < 0.0001). Graft occlusion occurred in 9 of the 21 SVGs (43%) that failed in the BMS group and in 2 of 4 SVGs (50%) that failed in the PES group. SVG failure after stenting presented as an acute coronary syndrome in 10 of the 24 patients (42%) (7 of those 10 patients presented with non-ST-segment elevation acute myocardial infarction), stable angina in 9 (37%) patients, and without symptoms in 5 (21%) patients. Of the 19 patients (with 20 grafts) who developed symptomatic graft failure, repeat SVG revascularization was successfully performed in all 13 (100%) subtotally obstructed SVGs but was attempted (and successful) in only 1 of 7 (14%) occluded SVGs. Revascularization of a native coronary artery was performed in an additional 4 of 7 (57%) symptomatic patients with an occluded SVG. Conclusions: SVG failure after stenting often presents as acute myocardial infarction and with SVG occlusion. Compared with BMS, PES reduce SVG failure.

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KW - bare-metal stents

KW - coronary artery bypass graft surgery

KW - drug-eluting stents

KW - outcomes

KW - percutaneous coronary intervention

KW - saphenous vein grafts

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