Clinical presentation of late-onset schizophrenia

M. J. Harris, C. M. Cullum, D. V. Jeste

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

DSM-III-R defines late-onset schizophrenia as schizophrenia that begins after age 45. The authors describe five patients who met DSM-III-R criteria for this disorder. The characteristic features of the disorder include bizarre delusions (usually of a persecutory nature), auditory hallucinations, a history of normal functioning at least until age 45, and a deterioration in personal-social functioning after the onset of illness. Physical examination, routine laboratory tests, neuropsychological evaluation, and magnetic resonance imaging (MRI) scans did not suggest the presence of any diagnosable organic mental disorder. In each of the five cases, mood disorders, delusional (paranoid) disorder, and schizophrenia with onset before age 45 were also considered in the differential diagnosis and ruled out. The authors' case vignettes support the premise that late-onset schizophrenia is a clinically diagnosable entity. Cautions in the diagnosis and treatment of such patients are discussed.

Original languageEnglish (US)
Pages (from-to)356-360
Number of pages5
JournalJournal of Clinical Psychiatry
Volume49
Issue number9
StatePublished - 1988

Fingerprint

Paranoid Schizophrenia
Schizophrenia
Diagnostic and Statistical Manual of Mental Disorders
Paranoid Disorders
Delusions
Neuropsychological Tests
Hallucinations
Mood Disorders
Age of Onset
Physical Examination
Differential Diagnosis
Magnetic Resonance Imaging
Therapeutics
Neurocognitive Disorders

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Clinical presentation of late-onset schizophrenia. / Harris, M. J.; Cullum, C. M.; Jeste, D. V.

In: Journal of Clinical Psychiatry, Vol. 49, No. 9, 1988, p. 356-360.

Research output: Contribution to journalArticle

Harris, MJ, Cullum, CM & Jeste, DV 1988, 'Clinical presentation of late-onset schizophrenia', Journal of Clinical Psychiatry, vol. 49, no. 9, pp. 356-360.
Harris, M. J. ; Cullum, C. M. ; Jeste, D. V. / Clinical presentation of late-onset schizophrenia. In: Journal of Clinical Psychiatry. 1988 ; Vol. 49, No. 9. pp. 356-360.
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