Clinical Presentation Patterns and Survival Outcomes of Hispanic Patients with Gastric Cancer

Gerardo A. Vitiello, Leena Hani, Annie Wang, Matthew R. Porembka, Rodrigo Alterio, Michelle Ju, Michael K. Turgeon, Rachel M. Lee, Maria C. Russell, Joshua Kronenfeld, Neha Goel, Jashodeep Datta, Ajay V. Maker, Manuel Fernandez, Harry Richter, Camilo Correa-Gallego, Russell S. Berman, Ann Y. Lee

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Hispanic patients have a higher incidence of gastric cancer when compared to non-Hispanics. Outlining clinicodemographic characteristics and assessing the impact of ethnicity on stage-specific survival may identify opportunities to improve gastric cancer care for this population. Methods: Patients with gastric cancer in the US Safety Net Collaborative (2012-2014) were retrospectively reviewed. Demographics, clinicopathologic characteristics, operative details, and outcomes were compared between Hispanic and non-Hispanic patients. Early onset gastric cancer was defined as age <50 years. Kaplan-Meier and Cox proportional-hazards models were used to identify the impact of ethnicity on disease-specific survival (DSS). Results: Seven hundred and ninety-seven patients were included, of which 219 (28%) were Hispanic. Hispanic patients were more likely to seek care at safety-net hospitals (66 vs 39%) and be uninsured (36 vs 17%), and less likely to have a primary care provider (PCP) (46 vs 75%; all P<0.05). Hispanic patients were twice as likely to present with early onset gastric cancer (28 vs 15%) and were more frequently diagnosed in the emergency room (54 vs 37%) with both abdominal pain and weight loss (44 vs 31%; all P <0.05). Treatment paradigms, operative outcomes, and DSS were similar between Hispanic and non-Hispanic patients when accounting for cancer stage. Cancer stage, pathologically positive nodes, and negative surgical margins were independently associated with DSS. Conclusions: A diagnosis of gastric cancer must be considered in previously healthy Hispanic patients who present to the emergency room with both abdominal pain and weight loss. Fewer than 50% of Hispanic patients have a PCP, indicating poor outpatient support. Efforts to improve outpatient support and screening may improve gastric cancer outcomes in this vulnerable population.

Original languageEnglish (US)
Pages (from-to)606-615
Number of pages10
JournalJournal of Surgical Research
Volume268
DOIs
StatePublished - Dec 2021

Keywords

  • Gastric cancer
  • Hispanic
  • Safety-net
  • Survival

ASJC Scopus subject areas

  • Surgery

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