Clinical review procedures for the Antiretroviral Pregnancy Registry

Angela Scheuerle, Deborah Covington

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The Antiretroviral Pregnancy Registry (APR) is an international pregnancy exposure registry designed to monitor prenatal antiretroviral medication exposures and detect any potential increase in the risk of major birth defects. The APR process imitates that of the Metropolitan Atlanta Congenital Defects Program (MACDP) modified to account for the differences in surveillance systems. The APR case definition attempts to separate prenatal and postnatal medication exposure, includes cases with multiple conditional defects only and collects cases diagnosed at later ages. Possible temporal association between defect pathogenesis and antiretroviral medication exposure includes a way to identify cases with known etiology - such as familial genetic conditions - and those with currently ambiguous pathogenesis - like hemangiomata and club feet. The APR also accounts for confounding factors like maternal alcohol use. Some defect reports automatically generate questions back to the reporter asking for more information. The APR incorporates procedures for managing and recording some of the more inconsistently reported malformations, such as microcephaly.

Original languageEnglish (US)
Pages (from-to)529-536
Number of pages8
JournalPharmacoepidemiology and Drug Safety
Volume13
Issue number8
DOIs
StatePublished - Aug 2004

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Registries
Pregnancy
Microcephaly
Hemangioma
Foot
Alcohols
Mothers

Keywords

  • Antiretroviral
  • Birth defect
  • Case definition
  • Pregnancy Registry

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Clinical review procedures for the Antiretroviral Pregnancy Registry. / Scheuerle, Angela; Covington, Deborah.

In: Pharmacoepidemiology and Drug Safety, Vol. 13, No. 8, 08.2004, p. 529-536.

Research output: Contribution to journalArticle

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