Clinical status of duplex RNA

Jonathan K. Watts, David R. Corey

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Double-stranded RNA has become a ubiquitous tool for inhibition of gene expression in the laboratory. If similar success could be achieved in vivo, duplex RNA might provide a new class of therapeutics capable of treating a broad spectrum of disease. Chemists and biologists developing duplex RNA as a drug have made progress but continue to face challenges. This review presents the current status of duplex RNA in the clinic and comments on future prospects for the approach.

Original languageEnglish (US)
Pages (from-to)3203-3207
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number11
DOIs
StatePublished - Jun 1 2010

Keywords

  • Nucleic acid therapeutic
  • RNAi
  • siRNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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