Clinical Trials in Spinal Muscular Atrophy: Protocol Development and Reliability of Quantitative Strength Assessment Method

Lisa Barker, Cindy Smith, Betsy Perkins, Karen Burhans, Rhonda Newman, Laurie Zimmerman, Jay Cook, Barry S. Russman, Frederick Samaha, Susan Iannaccone, C. Ralph Buncher, Michael White, Richard Browne

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

We have developed a protocol to evaluate, prospectively, patients with spinal muscular atrophy (SMA) so that the natural course may be defined and treatment efficacy measured. A fixed myometry system with a sensitivity of 0.5 kgs. of force was used to eliminate the subjectivity experienced with manual muscle testing and handheld dynamometry. Thirteen patients were evaluated weekly for twelve weeks by the clinical evaluators (CEs). Intrarater reliability was established by demonstrating that repeated measurements by the same examiner were consistent. The CEs examined patients at each of the participating institutions on three separate occasions. Interrater reliability was demonstrated by showing that the strength evaluations made on the same subject by different evaluators did not differ significantly. The fixed myometry system was found to be a highly reliable method for evaluating very weak muscle groups in patients with SMA.

Original languageEnglish (US)
Pages (from-to)175-183
Number of pages9
JournalNeurorehabilitation and Neural Repair
Volume6
Issue number4
DOIs
StatePublished - 1992

Keywords

  • Quantitative muscle strength assessment
  • Reliability
  • Spinal muscular atrophy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Rehabilitation

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    Barker, L., Smith, C., Perkins, B., Burhans, K., Newman, R., Zimmerman, L., Cook, J., Russman, B. S., Samaha, F., Iannaccone, S., Buncher, C. R., White, M., & Browne, R. (1992). Clinical Trials in Spinal Muscular Atrophy: Protocol Development and Reliability of Quantitative Strength Assessment Method. Neurorehabilitation and Neural Repair, 6(4), 175-183. https://doi.org/10.1177/136140969200600402