Clinical utility of the Japan-chronic total occlusion score in coronary chronic total occlusion interventions results from a multicenter registry

Georgios Christopoulos, Michael R. Wyman, Khaldoon Alaswad, Dimitri Karmpaliotis, William Lombardi, J. Aaron Grantham, Robert W. Yeh, Farouc A. Jaffer, Daisha J. Cipher, Bavana V. Rangan, Georgios E. Christakopoulos, Megan A. Kypreos, Nicholas Lembo, David Kandzari, Santiago Garcia, Craig A. Thompson, Subhash Banerjee, Emmanouil S. Brilakis

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Background-The performance of the Japan-chronic total occlusion (J-CTO) score in predicting success and efficiency of CTO percutaneous coronary intervention has received limited study. Methods and Results-We examined the records of 650 consecutive patients who underwent CTO percutaneous coronary intervention between 2011 and 2014 at 6 experienced centers in the United States. Six hundred and fifty-seven lesions were classified as easy (J-CTO=0), intermediate (J-CTO=1), difficult (J-CTO=2), and very difficult (J-CTO3). The impact of the J-CTO score on technical success and procedure time was evaluated with univariable logistic and linear regression, respectively. The performance of the logistic regression model was assessed with the Hosmer-Lemeshow statistic and receiver operator characteristic curves. Antegrade wiring techniques were used more frequently in easy lesions (97%) than very difficult lesions (58%), whereas the retrograde approach became more frequent with increased lesion difficulty (41% for very difficult lesions versus 13% for easy lesions). The logistic regression model for technical success demonstrated satisfactory calibration and discrimination (P for Hosmer-Lemeshow =0.743 and area under curve =0.705). The J-CTO score was associated with a 2-fold increase in the odds of technical failure (odds ratio 2.04, 95% confidence interval 1.52-2.80, P0.001). Procedure time increased by 20 minutes for every 1-point increase of the J-CTO score (regression coefficient 22.33, 95% confidence interval 17.45-27.22, P0.001). Conclusions-J-CTO score was strongly associated with final success and efficiency in this study, supporting its expanded use in CTO interventions.

Original languageEnglish (US)
Article numbere002171
JournalCirculation: Cardiovascular Interventions
Volume8
Issue number7
DOIs
StatePublished - May 1 2015

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Registries
Japan
Logistic Models
Percutaneous Coronary Intervention
Confidence Intervals
Calibration
Area Under Curve
Linear Models
Odds Ratio

Keywords

  • Chronic Total Occlusion
  • Complication
  • J-Cto Score
  • Outcome
  • Percutaneous Coronary Intervention
  • Radiation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Clinical utility of the Japan-chronic total occlusion score in coronary chronic total occlusion interventions results from a multicenter registry. / Christopoulos, Georgios; Wyman, Michael R.; Alaswad, Khaldoon; Karmpaliotis, Dimitri; Lombardi, William; Aaron Grantham, J.; Yeh, Robert W.; Jaffer, Farouc A.; Cipher, Daisha J.; Rangan, Bavana V.; Christakopoulos, Georgios E.; Kypreos, Megan A.; Lembo, Nicholas; Kandzari, David; Garcia, Santiago; Thompson, Craig A.; Banerjee, Subhash; Brilakis, Emmanouil S.

In: Circulation: Cardiovascular Interventions, Vol. 8, No. 7, e002171, 01.05.2015.

Research output: Contribution to journalArticle

Christopoulos, G, Wyman, MR, Alaswad, K, Karmpaliotis, D, Lombardi, W, Aaron Grantham, J, Yeh, RW, Jaffer, FA, Cipher, DJ, Rangan, BV, Christakopoulos, GE, Kypreos, MA, Lembo, N, Kandzari, D, Garcia, S, Thompson, CA, Banerjee, S & Brilakis, ES 2015, 'Clinical utility of the Japan-chronic total occlusion score in coronary chronic total occlusion interventions results from a multicenter registry', Circulation: Cardiovascular Interventions, vol. 8, no. 7, e002171. https://doi.org/10.1161/CIRCINTERVENTIONS.114.002171
Christopoulos, Georgios ; Wyman, Michael R. ; Alaswad, Khaldoon ; Karmpaliotis, Dimitri ; Lombardi, William ; Aaron Grantham, J. ; Yeh, Robert W. ; Jaffer, Farouc A. ; Cipher, Daisha J. ; Rangan, Bavana V. ; Christakopoulos, Georgios E. ; Kypreos, Megan A. ; Lembo, Nicholas ; Kandzari, David ; Garcia, Santiago ; Thompson, Craig A. ; Banerjee, Subhash ; Brilakis, Emmanouil S. / Clinical utility of the Japan-chronic total occlusion score in coronary chronic total occlusion interventions results from a multicenter registry. In: Circulation: Cardiovascular Interventions. 2015 ; Vol. 8, No. 7.
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abstract = "Background-The performance of the Japan-chronic total occlusion (J-CTO) score in predicting success and efficiency of CTO percutaneous coronary intervention has received limited study. Methods and Results-We examined the records of 650 consecutive patients who underwent CTO percutaneous coronary intervention between 2011 and 2014 at 6 experienced centers in the United States. Six hundred and fifty-seven lesions were classified as easy (J-CTO=0), intermediate (J-CTO=1), difficult (J-CTO=2), and very difficult (J-CTO3). The impact of the J-CTO score on technical success and procedure time was evaluated with univariable logistic and linear regression, respectively. The performance of the logistic regression model was assessed with the Hosmer-Lemeshow statistic and receiver operator characteristic curves. Antegrade wiring techniques were used more frequently in easy lesions (97{\%}) than very difficult lesions (58{\%}), whereas the retrograde approach became more frequent with increased lesion difficulty (41{\%} for very difficult lesions versus 13{\%} for easy lesions). The logistic regression model for technical success demonstrated satisfactory calibration and discrimination (P for Hosmer-Lemeshow =0.743 and area under curve =0.705). The J-CTO score was associated with a 2-fold increase in the odds of technical failure (odds ratio 2.04, 95{\%} confidence interval 1.52-2.80, P0.001). Procedure time increased by 20 minutes for every 1-point increase of the J-CTO score (regression coefficient 22.33, 95{\%} confidence interval 17.45-27.22, P0.001). Conclusions-J-CTO score was strongly associated with final success and efficiency in this study, supporting its expanded use in CTO interventions.",
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AU - Alaswad, Khaldoon

AU - Karmpaliotis, Dimitri

AU - Lombardi, William

AU - Aaron Grantham, J.

AU - Yeh, Robert W.

AU - Jaffer, Farouc A.

AU - Cipher, Daisha J.

AU - Rangan, Bavana V.

AU - Christakopoulos, Georgios E.

AU - Kypreos, Megan A.

AU - Lembo, Nicholas

AU - Kandzari, David

AU - Garcia, Santiago

AU - Thompson, Craig A.

AU - Banerjee, Subhash

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