Clinico-pathological features and outcome in adult patients with Henoch-Schönlein purpura nephritis

Yuki Tsuruta, Takashi Takei, Mari Takano, Yukako Sawara, Akiko Aoki, Aya Eguchi, Chiari Kojima, Takahito Moriyama, Mitsuyo Itabashi, Hidekazu Sugiura, Misao Tsukada, Tetsuya Ogawa, Takumi Yoshida, Keiko Uchida, Ken Tsuchiya, Kosaku Nitta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We examined the data of 24 patients with Henoch-Schönlein purpura nephritis (HSPN) over a 5-year follow-up period. Proteinuria, sediment RBC and CRP significantly decreased between the time of diagnosis and the end of the 5-year period. In the steroid usage group (n= 16), proteinuria was significantly higher, and crescent formation was significant higher at the time of diagnosis than in the non-steroid usage group (n=8). However, there was no significant difference in the decrease in eGFR from the baseline at the end of the 5-year period between the two groups. Furthermore, to clarify the factors influencing the risk of renal function deterioration, we divided the patients into two groups, the (ΔeGFR/pre eGFR) <0.25 group (n= 13) and (ΔeGFR/pre eGFR) >0.25 group(n=11), and compared the clinico-pathophysiological characteristics between the two groups. In the (ΔeGFR/pre eGFR) >0.25 group, the ratio of glomerular obsolescence at the time of diagnosis was significantly higher than in the (ΔeGFR/pre eGFR) <0.25 group. Glomerular obsolescence was identified as an independent risk factor for renal function deterioration. In this study, the prognosis of HSPN was related to glomerular obsolescence rather than to the disease activity. It may be necessary to consider the decrease in nephrons, in accordance with non-immunological glomerular obsolescence, in addition to immunological treatment to clarify the prognosis.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalJapanese Journal of Nephrology
Volume52
Issue number1
StatePublished - 2010

Fingerprint

Schoenlein-Henoch Purpura
Nephritis
Proteinuria
Kidney
Nephrons
Steroids
Therapeutics

Keywords

  • Glomerular obsolescence
  • HSPN
  • Renal function

ASJC Scopus subject areas

  • Nephrology

Cite this

Tsuruta, Y., Takei, T., Takano, M., Sawara, Y., Aoki, A., Eguchi, A., ... Nitta, K. (2010). Clinico-pathological features and outcome in adult patients with Henoch-Schönlein purpura nephritis. Japanese Journal of Nephrology, 52(1), 51-57.

Clinico-pathological features and outcome in adult patients with Henoch-Schönlein purpura nephritis. / Tsuruta, Yuki; Takei, Takashi; Takano, Mari; Sawara, Yukako; Aoki, Akiko; Eguchi, Aya; Kojima, Chiari; Moriyama, Takahito; Itabashi, Mitsuyo; Sugiura, Hidekazu; Tsukada, Misao; Ogawa, Tetsuya; Yoshida, Takumi; Uchida, Keiko; Tsuchiya, Ken; Nitta, Kosaku.

In: Japanese Journal of Nephrology, Vol. 52, No. 1, 2010, p. 51-57.

Research output: Contribution to journalArticle

Tsuruta, Y, Takei, T, Takano, M, Sawara, Y, Aoki, A, Eguchi, A, Kojima, C, Moriyama, T, Itabashi, M, Sugiura, H, Tsukada, M, Ogawa, T, Yoshida, T, Uchida, K, Tsuchiya, K & Nitta, K 2010, 'Clinico-pathological features and outcome in adult patients with Henoch-Schönlein purpura nephritis', Japanese Journal of Nephrology, vol. 52, no. 1, pp. 51-57.
Tsuruta, Yuki ; Takei, Takashi ; Takano, Mari ; Sawara, Yukako ; Aoki, Akiko ; Eguchi, Aya ; Kojima, Chiari ; Moriyama, Takahito ; Itabashi, Mitsuyo ; Sugiura, Hidekazu ; Tsukada, Misao ; Ogawa, Tetsuya ; Yoshida, Takumi ; Uchida, Keiko ; Tsuchiya, Ken ; Nitta, Kosaku. / Clinico-pathological features and outcome in adult patients with Henoch-Schönlein purpura nephritis. In: Japanese Journal of Nephrology. 2010 ; Vol. 52, No. 1. pp. 51-57.
@article{09a556eadf294db782e467dccd6e0f7a,
title = "Clinico-pathological features and outcome in adult patients with Henoch-Sch{\"o}nlein purpura nephritis",
abstract = "We examined the data of 24 patients with Henoch-Sch{\"o}nlein purpura nephritis (HSPN) over a 5-year follow-up period. Proteinuria, sediment RBC and CRP significantly decreased between the time of diagnosis and the end of the 5-year period. In the steroid usage group (n= 16), proteinuria was significantly higher, and crescent formation was significant higher at the time of diagnosis than in the non-steroid usage group (n=8). However, there was no significant difference in the decrease in eGFR from the baseline at the end of the 5-year period between the two groups. Furthermore, to clarify the factors influencing the risk of renal function deterioration, we divided the patients into two groups, the (ΔeGFR/pre eGFR) <0.25 group (n= 13) and (ΔeGFR/pre eGFR) >0.25 group(n=11), and compared the clinico-pathophysiological characteristics between the two groups. In the (ΔeGFR/pre eGFR) >0.25 group, the ratio of glomerular obsolescence at the time of diagnosis was significantly higher than in the (ΔeGFR/pre eGFR) <0.25 group. Glomerular obsolescence was identified as an independent risk factor for renal function deterioration. In this study, the prognosis of HSPN was related to glomerular obsolescence rather than to the disease activity. It may be necessary to consider the decrease in nephrons, in accordance with non-immunological glomerular obsolescence, in addition to immunological treatment to clarify the prognosis.",
keywords = "Glomerular obsolescence, HSPN, Renal function",
author = "Yuki Tsuruta and Takashi Takei and Mari Takano and Yukako Sawara and Akiko Aoki and Aya Eguchi and Chiari Kojima and Takahito Moriyama and Mitsuyo Itabashi and Hidekazu Sugiura and Misao Tsukada and Tetsuya Ogawa and Takumi Yoshida and Keiko Uchida and Ken Tsuchiya and Kosaku Nitta",
year = "2010",
language = "English (US)",
volume = "52",
pages = "51--57",
journal = "Nihon Jinzo Gakkai shi",
issn = "0385-2385",
publisher = "Japanese Society of Nephrology",
number = "1",

}

TY - JOUR

T1 - Clinico-pathological features and outcome in adult patients with Henoch-Schönlein purpura nephritis

AU - Tsuruta, Yuki

AU - Takei, Takashi

AU - Takano, Mari

AU - Sawara, Yukako

AU - Aoki, Akiko

AU - Eguchi, Aya

AU - Kojima, Chiari

AU - Moriyama, Takahito

AU - Itabashi, Mitsuyo

AU - Sugiura, Hidekazu

AU - Tsukada, Misao

AU - Ogawa, Tetsuya

AU - Yoshida, Takumi

AU - Uchida, Keiko

AU - Tsuchiya, Ken

AU - Nitta, Kosaku

PY - 2010

Y1 - 2010

N2 - We examined the data of 24 patients with Henoch-Schönlein purpura nephritis (HSPN) over a 5-year follow-up period. Proteinuria, sediment RBC and CRP significantly decreased between the time of diagnosis and the end of the 5-year period. In the steroid usage group (n= 16), proteinuria was significantly higher, and crescent formation was significant higher at the time of diagnosis than in the non-steroid usage group (n=8). However, there was no significant difference in the decrease in eGFR from the baseline at the end of the 5-year period between the two groups. Furthermore, to clarify the factors influencing the risk of renal function deterioration, we divided the patients into two groups, the (ΔeGFR/pre eGFR) <0.25 group (n= 13) and (ΔeGFR/pre eGFR) >0.25 group(n=11), and compared the clinico-pathophysiological characteristics between the two groups. In the (ΔeGFR/pre eGFR) >0.25 group, the ratio of glomerular obsolescence at the time of diagnosis was significantly higher than in the (ΔeGFR/pre eGFR) <0.25 group. Glomerular obsolescence was identified as an independent risk factor for renal function deterioration. In this study, the prognosis of HSPN was related to glomerular obsolescence rather than to the disease activity. It may be necessary to consider the decrease in nephrons, in accordance with non-immunological glomerular obsolescence, in addition to immunological treatment to clarify the prognosis.

AB - We examined the data of 24 patients with Henoch-Schönlein purpura nephritis (HSPN) over a 5-year follow-up period. Proteinuria, sediment RBC and CRP significantly decreased between the time of diagnosis and the end of the 5-year period. In the steroid usage group (n= 16), proteinuria was significantly higher, and crescent formation was significant higher at the time of diagnosis than in the non-steroid usage group (n=8). However, there was no significant difference in the decrease in eGFR from the baseline at the end of the 5-year period between the two groups. Furthermore, to clarify the factors influencing the risk of renal function deterioration, we divided the patients into two groups, the (ΔeGFR/pre eGFR) <0.25 group (n= 13) and (ΔeGFR/pre eGFR) >0.25 group(n=11), and compared the clinico-pathophysiological characteristics between the two groups. In the (ΔeGFR/pre eGFR) >0.25 group, the ratio of glomerular obsolescence at the time of diagnosis was significantly higher than in the (ΔeGFR/pre eGFR) <0.25 group. Glomerular obsolescence was identified as an independent risk factor for renal function deterioration. In this study, the prognosis of HSPN was related to glomerular obsolescence rather than to the disease activity. It may be necessary to consider the decrease in nephrons, in accordance with non-immunological glomerular obsolescence, in addition to immunological treatment to clarify the prognosis.

KW - Glomerular obsolescence

KW - HSPN

KW - Renal function

UR - http://www.scopus.com/inward/record.url?scp=77249170900&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77249170900&partnerID=8YFLogxK

M3 - Article

C2 - 20166542

AN - SCOPUS:77249170900

VL - 52

SP - 51

EP - 57

JO - Nihon Jinzo Gakkai shi

JF - Nihon Jinzo Gakkai shi

SN - 0385-2385

IS - 1

ER -