TY - JOUR
T1 - Clinicopathologic correlation of epidemiologic and histopathologic features of pediatric bacterial lymphadenitis
AU - Nunes Rosado, Flavia G.
AU - Stratton, Charles W.
AU - Mosse, Claudio A.
PY - 2011/11
Y1 - 2011/11
N2 - Context.-Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing. Objective.-To assess and compare the histopathologic and epidemiologic features of common and uncommon pediatric bacterial lymphadenitis. Design.-We searched our database for surgical specimens that had a positive identification of bacteria during an 8-year period. The chart was reviewed to assess the pathogen identified and epidemiologic data. The archival tissue sections were reviewed and the histopathologic findings described for each pathogen. Results.-The review of 368 pediatric lymph node biopsies identified 33 cases with a bacterial infection. These comprised 21 cases of Mycobacterium avium complex (60%), 1 of Mycobacterium fortuitum (3%), 7 of Bartonella henselae (20%), 2 of Yersinia enterocolitica (7%), 1 of Francisella tularensis (3%) and 1 of Streptococcus pyogenes (3%). Conclusions.-Each of these infectious lymphadenitides had distinct epidemiologic and histopathologic features that are discussed in this report.
AB - Context.-Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing. Objective.-To assess and compare the histopathologic and epidemiologic features of common and uncommon pediatric bacterial lymphadenitis. Design.-We searched our database for surgical specimens that had a positive identification of bacteria during an 8-year period. The chart was reviewed to assess the pathogen identified and epidemiologic data. The archival tissue sections were reviewed and the histopathologic findings described for each pathogen. Results.-The review of 368 pediatric lymph node biopsies identified 33 cases with a bacterial infection. These comprised 21 cases of Mycobacterium avium complex (60%), 1 of Mycobacterium fortuitum (3%), 7 of Bartonella henselae (20%), 2 of Yersinia enterocolitica (7%), 1 of Francisella tularensis (3%) and 1 of Streptococcus pyogenes (3%). Conclusions.-Each of these infectious lymphadenitides had distinct epidemiologic and histopathologic features that are discussed in this report.
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U2 - 10.5858/arpa.2010-0581-OA
DO - 10.5858/arpa.2010-0581-OA
M3 - Article
C2 - 22032579
AN - SCOPUS:82555173063
VL - 135
SP - 1490
EP - 1493
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
SN - 0003-9985
IS - 11
ER -