Clinicopathologic features of CD5-positive nodal marginal zone lymphoma

Jesse Manuel Jaso, C. Cameron Yin, Sa A. Wang, Roberto N. Miranda, Christine E. Jabcuga, Lei Chen, L. Jeffrey Medeiros

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objectives: To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL). Methods: We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL. Results: Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months). Conclusions: CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.

Original languageEnglish (US)
Pages (from-to)693-700
Number of pages8
JournalAmerican journal of clinical pathology
Volume140
Issue number5
DOIs
StatePublished - Nov 1 2013

Keywords

  • CD5
  • Nodal marginal zone lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Jaso, J. M., Yin, C. C., Wang, S. A., Miranda, R. N., Jabcuga, C. E., Chen, L., & Medeiros, L. J. (2013). Clinicopathologic features of CD5-positive nodal marginal zone lymphoma. American journal of clinical pathology, 140(5), 693-700. https://doi.org/10.1309/AJCPEMVXES72DUIF