Clinicopathologic features of CD5-positive nodal marginal zone lymphoma

Jesse Manuel Jaso, C. Cameron Yin, Sa A. Wang, Roberto N. Miranda, Christine E. Jabcuga, Lei Chen, L. Jeffrey Medeiros

Research output: Contribution to journalArticle

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Abstract

Objectives: To describe the clinicopathologic findings of seven patients with CD5-positive nodal marginal zone lymphoma (NMZL). Methods: We searched cases of NMZL over a 10-year interval and identified seven cases of CD5-positive NMZL. The clinical, histologic, and immunophenotypic findings of this group were reviewed, and the frequency of dissemination in this group was compared with that of 66 patients with CD5-negative NMZL. Results: Other than CD5 expression, the histologic and immunophenotypic findings were typical of NMZL. Six (86%) of seven patients had lymphadenopathy above and below the diaphragm, and all six patients assessed had bone marrow involvement. In the CD5-negative group, 28 (42%) patients had lymphadenopathy above and below the diaphragm, and 36 (55%) had bone marrow involvement (P = .045 and P = .037, respectively). Six of seven patients were alive at last follow-up, with a median follow-up of 32 months (3-154 months). Conclusions: CD5 expression in NMZL correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.

Original languageEnglish (US)
Pages (from-to)693-700
Number of pages8
JournalAmerican Journal of Clinical Pathology
Volume140
Issue number5
DOIs
StatePublished - Nov 1 2013

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Lymphoma
Diaphragm
Bone Marrow
Survival

Keywords

  • CD5
  • Nodal marginal zone lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Jaso, J. M., Yin, C. C., Wang, S. A., Miranda, R. N., Jabcuga, C. E., Chen, L., & Medeiros, L. J. (2013). Clinicopathologic features of CD5-positive nodal marginal zone lymphoma. American Journal of Clinical Pathology, 140(5), 693-700. https://doi.org/10.1309/AJCPEMVXES72DUIF

Clinicopathologic features of CD5-positive nodal marginal zone lymphoma. / Jaso, Jesse Manuel; Yin, C. Cameron; Wang, Sa A.; Miranda, Roberto N.; Jabcuga, Christine E.; Chen, Lei; Medeiros, L. Jeffrey.

In: American Journal of Clinical Pathology, Vol. 140, No. 5, 01.11.2013, p. 693-700.

Research output: Contribution to journalArticle

Jaso, JM, Yin, CC, Wang, SA, Miranda, RN, Jabcuga, CE, Chen, L & Medeiros, LJ 2013, 'Clinicopathologic features of CD5-positive nodal marginal zone lymphoma', American Journal of Clinical Pathology, vol. 140, no. 5, pp. 693-700. https://doi.org/10.1309/AJCPEMVXES72DUIF
Jaso, Jesse Manuel ; Yin, C. Cameron ; Wang, Sa A. ; Miranda, Roberto N. ; Jabcuga, Christine E. ; Chen, Lei ; Medeiros, L. Jeffrey. / Clinicopathologic features of CD5-positive nodal marginal zone lymphoma. In: American Journal of Clinical Pathology. 2013 ; Vol. 140, No. 5. pp. 693-700.
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