Clinicopathological patterns of drug-induced liver disease

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The liver ranks high on the list of targets affected by adverse reactions to therapeutic or environmental agents (1-4). Awareness of drug-induced reactions affecting the liver has become increasingly a matter of concern. The clinical manifestations of drug-induced liver injury cover the full spectrum of liver disorders. It is often difficult and occasionally impossible to separate clinical manifestation caused by a drug from those caused by the underlying illness. Of particular concern are those drug-induced injuries that lead to clinically severe liver disease and acute liver failure (5). Much attention has been focused on drugs that were evaluated and approved, which later were withdrawn because of hepatotoxicity. The challenge is to improve the methods by which potential hepatotoxicity is identified so as to assure that an accurate assessment of risk is made.

Original languageEnglish (US)
Title of host publicationDrug-Induced Liver Disease, Second Edition
PublisherCRC Press
Pages223-236
Number of pages14
ISBN (Electronic)9781420021141
ISBN (Print)9780849398964
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Maddrey, W. C. (2007). Clinicopathological patterns of drug-induced liver disease. In Drug-Induced Liver Disease, Second Edition (pp. 223-236). CRC Press.