CLN3P, the Batten disease protein, localizes to membrane lipid rafts (detergent-resistant membranes)

Dinesh Rakheja, Srinivas B. Narayan, Johanne V. Pastor, Michael J. Bennett

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Juvenile neuronal ceroid lipofuscinosis is an inherited pediatric neurodegenerative disorder, which occurs as a result of mutations in the CLN3 gene that is located on chromosome 16p12.1. The encoded protein, CLN3P, is a putative transmembrane protein with no known function. In this study, we demonstrate that CLN3P resides on membrane lipid raft domains (detergent-resistant membranes) and provide important new data towards possible functions of the protein.

Original languageEnglish (US)
Pages (from-to)988-991
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume317
Issue number4
DOIs
StatePublished - May 14 2004

Keywords

  • CLN3
  • CLN3P
  • JNCL
  • Juvenile neuronal ceroid lipofuscinosis
  • Lipid rafts

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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