Clofibrate, caloric restriction, supersaturation of bile, and cholesterol crystals

Y. A. Kesäniemi, Scott M Grundy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lipid composition, cholesterol saturation, and cholesterol crystal formation of gallbladder bile were studied in seven type-IV hyperlipoproteinemic subjects who did not have gallstones. Thereafter, biliary cholesterol solubilization was overloaded, first by clofibrate and then by caloric restriction treatment. Initially increased cholesterol saturation was still increased by both clofibrate and caloric restriction treatment, but none of the subjects developed cholesterol crystals in bile, indicating that they had a mechanism to maintain cholesterol in solution in the bile despite remarkable supersaturation. This suggests that the patients who are at risk of developing gallstones can be better selected by cholesterol crystal analysis of bile samples than by analysis of lipid composition of bile.

Original languageEnglish (US)
Pages (from-to)897-902
Number of pages6
JournalScandinavian Journal of Gastroenterology
Volume18
Issue number7
DOIs
StatePublished - 1983

Fingerprint

Clofibrate
Caloric Restriction
Bile
Cholesterol
Gallstones
Lipids
Gallbladder
Therapeutics

Keywords

  • Bile saturation
  • Biliary lipids
  • Caloric restriction
  • Cholesterol crystals
  • Clofibrate
  • Hyperlipoproteinemias
  • Hypertriglyceridemia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Clofibrate, caloric restriction, supersaturation of bile, and cholesterol crystals. / Kesäniemi, Y. A.; Grundy, Scott M.

In: Scandinavian Journal of Gastroenterology, Vol. 18, No. 7, 1983, p. 897-902.

Research output: Contribution to journalArticle

@article{0fd2db3370804eb29b729199df2be8db,
title = "Clofibrate, caloric restriction, supersaturation of bile, and cholesterol crystals",
abstract = "Lipid composition, cholesterol saturation, and cholesterol crystal formation of gallbladder bile were studied in seven type-IV hyperlipoproteinemic subjects who did not have gallstones. Thereafter, biliary cholesterol solubilization was overloaded, first by clofibrate and then by caloric restriction treatment. Initially increased cholesterol saturation was still increased by both clofibrate and caloric restriction treatment, but none of the subjects developed cholesterol crystals in bile, indicating that they had a mechanism to maintain cholesterol in solution in the bile despite remarkable supersaturation. This suggests that the patients who are at risk of developing gallstones can be better selected by cholesterol crystal analysis of bile samples than by analysis of lipid composition of bile.",
keywords = "Bile saturation, Biliary lipids, Caloric restriction, Cholesterol crystals, Clofibrate, Hyperlipoproteinemias, Hypertriglyceridemia",
author = "Kes{\"a}niemi, {Y. A.} and Grundy, {Scott M}",
year = "1983",
doi = "10.3109/00365528309182112",
language = "English (US)",
volume = "18",
pages = "897--902",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Informa Healthcare",
number = "7",

}

TY - JOUR

T1 - Clofibrate, caloric restriction, supersaturation of bile, and cholesterol crystals

AU - Kesäniemi, Y. A.

AU - Grundy, Scott M

PY - 1983

Y1 - 1983

N2 - Lipid composition, cholesterol saturation, and cholesterol crystal formation of gallbladder bile were studied in seven type-IV hyperlipoproteinemic subjects who did not have gallstones. Thereafter, biliary cholesterol solubilization was overloaded, first by clofibrate and then by caloric restriction treatment. Initially increased cholesterol saturation was still increased by both clofibrate and caloric restriction treatment, but none of the subjects developed cholesterol crystals in bile, indicating that they had a mechanism to maintain cholesterol in solution in the bile despite remarkable supersaturation. This suggests that the patients who are at risk of developing gallstones can be better selected by cholesterol crystal analysis of bile samples than by analysis of lipid composition of bile.

AB - Lipid composition, cholesterol saturation, and cholesterol crystal formation of gallbladder bile were studied in seven type-IV hyperlipoproteinemic subjects who did not have gallstones. Thereafter, biliary cholesterol solubilization was overloaded, first by clofibrate and then by caloric restriction treatment. Initially increased cholesterol saturation was still increased by both clofibrate and caloric restriction treatment, but none of the subjects developed cholesterol crystals in bile, indicating that they had a mechanism to maintain cholesterol in solution in the bile despite remarkable supersaturation. This suggests that the patients who are at risk of developing gallstones can be better selected by cholesterol crystal analysis of bile samples than by analysis of lipid composition of bile.

KW - Bile saturation

KW - Biliary lipids

KW - Caloric restriction

KW - Cholesterol crystals

KW - Clofibrate

KW - Hyperlipoproteinemias

KW - Hypertriglyceridemia

UR - http://www.scopus.com/inward/record.url?scp=0020576353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020576353&partnerID=8YFLogxK

U2 - 10.3109/00365528309182112

DO - 10.3109/00365528309182112

M3 - Article

C2 - 6676922

AN - SCOPUS:0020576353

VL - 18

SP - 897

EP - 902

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 7

ER -