Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate

Michael E. Ray, Kirk J. Wojno, Neal S. Goldstein, Karin B. Olson, Rajal B. Shah, Kathleen A. Cooney

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Sarcomatoid carcinomas of the prostate are rare malignancies composed of carcinomatous and sarcomatous elements. Their etiology is uncertain and may represent a single malignant process or a mixture of two distinct malignancies. We report a clinical case of a patient who presented with locally advanced disease and was treated with hormonal and cytotoxic chemotherapy, but ultimately developed distant metastasis and died of the disease. A loss-of-heterozygosity analysis of the primary and metastatic tissues provided compelling evidence that the carcinomatous and sarcomatous elements are clonally related, supporting the hypothesis that a single malignant process underlies the etiology of sarcomatoid carcinoma of the prostate.

Original languageEnglish (US)
Pages (from-to)423.e5-423.e8
JournalUrology
Volume67
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

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Prostate
Carcinoma
Neoplasms
Loss of Heterozygosity
Neoplasm Metastasis
Drug Therapy

ASJC Scopus subject areas

  • Urology

Cite this

Ray, M. E., Wojno, K. J., Goldstein, N. S., Olson, K. B., Shah, R. B., & Cooney, K. A. (2006). Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate. Urology, 67(2), 423.e5-423.e8. https://doi.org/10.1016/j.urology.2005.08.013

Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate. / Ray, Michael E.; Wojno, Kirk J.; Goldstein, Neal S.; Olson, Karin B.; Shah, Rajal B.; Cooney, Kathleen A.

In: Urology, Vol. 67, No. 2, 02.2006, p. 423.e5-423.e8.

Research output: Contribution to journalArticle

Ray, ME, Wojno, KJ, Goldstein, NS, Olson, KB, Shah, RB & Cooney, KA 2006, 'Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate', Urology, vol. 67, no. 2, pp. 423.e5-423.e8. https://doi.org/10.1016/j.urology.2005.08.013
Ray, Michael E. ; Wojno, Kirk J. ; Goldstein, Neal S. ; Olson, Karin B. ; Shah, Rajal B. ; Cooney, Kathleen A. / Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate. In: Urology. 2006 ; Vol. 67, No. 2. pp. 423.e5-423.e8.
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