Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate

Michael E. Ray, Kirk J. Wojno, Neal S. Goldstein, Karin B. Olson, Rajal B. Shah, Kathleen A. Cooney

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Sarcomatoid carcinomas of the prostate are rare malignancies composed of carcinomatous and sarcomatous elements. Their etiology is uncertain and may represent a single malignant process or a mixture of two distinct malignancies. We report a clinical case of a patient who presented with locally advanced disease and was treated with hormonal and cytotoxic chemotherapy, but ultimately developed distant metastasis and died of the disease. A loss-of-heterozygosity analysis of the primary and metastatic tissues provided compelling evidence that the carcinomatous and sarcomatous elements are clonally related, supporting the hypothesis that a single malignant process underlies the etiology of sarcomatoid carcinoma of the prostate.

Original languageEnglish (US)
Pages (from-to)423.e5-423.e8
JournalUrology
Volume67
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate'. Together they form a unique fingerprint.

  • Cite this

    Ray, M. E., Wojno, K. J., Goldstein, N. S., Olson, K. B., Shah, R. B., & Cooney, K. A. (2006). Clonality of sarcomatous and carcinomatous elements in sarcomatoid carcinoma of the prostate. Urology, 67(2), 423.e5-423.e8. https://doi.org/10.1016/j.urology.2005.08.013