Cloning and characterization of a specific cytokeratin-8 cDNA from rat prostatic epithelium

X. Wang, J. T. Hsieh, H. E. Zhau

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Abstract

In this study, we report the cloning and sequencing of a full-length cytokeratin-8 (CK-8) cDNA from a rat prostatic epithelial cDNA library. The effects of androgen on CK-8 expression in rat prostate were also studied. The data indicated that the steady-state level of CK-8 mRNA was elevated by about 5- to 10-fold in both prostate and seminal vesicles in castrated rats, and the elevated levels persisted during a 23-day experimental period. Androgen but not estrogen administration repressed the expression of CK-8 mRNA. This effect could be antagonized by the simultaneous administration of an antiandrogen, flutamide, indicating that CK-8 is a new class of androgen-repressed genes whose regulation is presumably mediated by androgen receptor mechanisms.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Volume16
Issue number1
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Medicine(all)

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