Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta1

Quan Sheng Yang; Kang Ying; Hong Ling Yuan; Jin Zhong Chen; Xian Fang Meng; Zhao Wang; Yi Xie; Yu Min Mao

doi:10.1016/S0167-4781(01)00319-0

Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta¹

Quan Sheng Yang, Kang Ying, Hong Ling Yuan, Jin Zhong Chen, Xian Fang Meng, Zhao Wang, Yi Xie, Yu Min Mao

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library. The mRNA was predominantly expressed in placenta, while the expression of it was not or barely detectable in heart, brain, lung, liver, skeletal muscle, kidney, and pancreas by Northern blot. COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal. STS of Unigene Hs. 24236 placed the cDNA to human chromosome 19q13.2.

Original language	English (US)
Pages (from-to)	407-411
Number of pages	5
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1574
Issue number	3
DOIs	https://doi.org/10.1016/S0167-4781(01)00319-0
State	Published - Apr 12 2002

Keywords

Galectin
Nuclear localization signal
Placenta
Unigene

ASJC Scopus subject areas

Structural Biology
Biophysics
Biochemistry
Genetics

Access to Document

10.1016/S0167-4781(01)00319-0

Cite this

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title = "Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta1",

abstract = "A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library. The mRNA was predominantly expressed in placenta, while the expression of it was not or barely detectable in heart, brain, lung, liver, skeletal muscle, kidney, and pancreas by Northern blot. COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal. STS of Unigene Hs. 24236 placed the cDNA to human chromosome 19q13.2.",

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T1 - Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta1

AU - Yang, Quan Sheng

AU - Ying, Kang

AU - Yuan, Hong Ling

AU - Chen, Jin Zhong

AU - Meng, Xian Fang

AU - Wang, Zhao

AU - Xie, Yi

AU - Mao, Yu Min

PY - 2002/4/12

Y1 - 2002/4/12

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AB - A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library. The mRNA was predominantly expressed in placenta, while the expression of it was not or barely detectable in heart, brain, lung, liver, skeletal muscle, kidney, and pancreas by Northern blot. COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal. STS of Unigene Hs. 24236 placed the cDNA to human chromosome 19q13.2.

KW - Galectin

KW - Nuclear localization signal

KW - Placenta

KW - Unigene

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