Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta1

Quan Sheng Yang, Kang Ying, Hong Ling Yuan, Jin Zhong Chen, Xian Fang Meng, Zhao Wang, Yi Xie, Yu Min Mao

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library. The mRNA was predominantly expressed in placenta, while the expression of it was not or barely detectable in heart, brain, lung, liver, skeletal muscle, kidney, and pancreas by Northern blot. COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal. STS of Unigene Hs. 24236 placed the cDNA to human chromosome 19q13.2.

Original languageEnglish (US)
Pages (from-to)407-411
Number of pages5
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1574
Issue number3
DOIs
StatePublished - Apr 12 2002

Keywords

  • Galectin
  • Nuclear localization signal
  • Placenta
  • Unigene

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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