Closed-loop control of epileptic seizures via deep brain stimulation in a rodent model of chronic epilepsy

L. D. Iasemidis, S. Sabesan, L. B. Good, K. Tsakalis, D. M. Treiman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have designed and implemented an automated, just-in-time seizure control scheme using a seizure prediction method coupled with deep brain stimulation in the centromedial thalamic nuclei of epileptic rats. The scheme was tested in terms of its efficacy to control seizures, as well as its effect on synchronization of brain dynamics. The proposed technique of just-in-time stimulation resulted to a significant (>50%) reduction of seizure frequency as compared to a baseline period with no stimulation. Importantly, we show that successful seizure control was highly correlated with desynchronization of brain dynamics. This study provides initial evidence for the efficacy of closed-loop feedback control systems in epileptic seizures combining methods from seizure prediction and deep brain stimulation.

Original languageEnglish (US)
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationNeuroengineering, Neural Systems, Rehabilitation and Prosthetics
Pages588-591
Number of pages4
Edition9
DOIs
StatePublished - Dec 1 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Publication series

NameIFMBE Proceedings
Number9
Volume25
ISSN (Print)1680-0737

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics
CountryGermany
CityMunich
Period9/7/099/12/09

Keywords

  • Deep brain stimulation
  • Desynchronization
  • Feedback control
  • Seizure prediction

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

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  • Cite this

    Iasemidis, L. D., Sabesan, S., Good, L. B., Tsakalis, K., & Treiman, D. M. (2009). Closed-loop control of epileptic seizures via deep brain stimulation in a rodent model of chronic epilepsy. In World Congress on Medical Physics and Biomedical Engineering: Neuroengineering, Neural Systems, Rehabilitation and Prosthetics (9 ed., pp. 588-591). (IFMBE Proceedings; Vol. 25, No. 9). https://doi.org/10.1007/978-3-642-03889-1-159