Closed-loop dynamic modeling of cerebral hemodynamics

V. Z. Marmarelis, D. C. Shin, M. E. Orme, R. Zhang

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The dynamics of cerebral hemodynamics have been studied extensively because of their fundamental physiological and clinical importance. In particular, the dynamic processes of cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity have attracted broad attention because of their involvement in a host of pathologies and clinical conditions (e.g., hypertension, syncope, stroke, traumatic brain injury, vascular dementia, Alzheimer's disease, mild cognitive impairment etc.). This raises the prospect of useful diagnostic methods being developed on the basis of quantitative models of cerebral hemodynamics, if cerebral vascular dysfunction can be quantified reliably from data collected within practical clinical constraints. This paper presents a modeling method that utilizes beat-to-beat measurements of mean arterial blood pressure, cerebral blood flow velocity and end-tidal CO2 (collected non-invasively under resting conditions) to quantify the dynamics of CFA and cerebral vasomotor reactivity (CVMR). The unique and novel aspect of this dynamic model is that it is nonlinear and operates in a closed-loop configuration.

Original languageEnglish (US)
Pages (from-to)1029-1048
Number of pages20
JournalAnnals of Biomedical Engineering
Volume41
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Hemodynamics
Blood pressure
Pathology
Flow velocity
Dynamic models
Brain
Blood

Keywords

  • Cerebral autoregulation
  • Cerebral flow autoregulation
  • Cerebral vasomotor reactivity
  • Closed-loop modeling
  • Modeling cerebral hemodynamics
  • Nonlinear modeling

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Closed-loop dynamic modeling of cerebral hemodynamics. / Marmarelis, V. Z.; Shin, D. C.; Orme, M. E.; Zhang, R.

In: Annals of Biomedical Engineering, Vol. 41, No. 5, 05.2013, p. 1029-1048.

Research output: Contribution to journalArticle

Marmarelis, V. Z. ; Shin, D. C. ; Orme, M. E. ; Zhang, R. / Closed-loop dynamic modeling of cerebral hemodynamics. In: Annals of Biomedical Engineering. 2013 ; Vol. 41, No. 5. pp. 1029-1048.
@article{fa6f236f719e46d7b1e05516167996ad,
title = "Closed-loop dynamic modeling of cerebral hemodynamics",
abstract = "The dynamics of cerebral hemodynamics have been studied extensively because of their fundamental physiological and clinical importance. In particular, the dynamic processes of cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity have attracted broad attention because of their involvement in a host of pathologies and clinical conditions (e.g., hypertension, syncope, stroke, traumatic brain injury, vascular dementia, Alzheimer's disease, mild cognitive impairment etc.). This raises the prospect of useful diagnostic methods being developed on the basis of quantitative models of cerebral hemodynamics, if cerebral vascular dysfunction can be quantified reliably from data collected within practical clinical constraints. This paper presents a modeling method that utilizes beat-to-beat measurements of mean arterial blood pressure, cerebral blood flow velocity and end-tidal CO2 (collected non-invasively under resting conditions) to quantify the dynamics of CFA and cerebral vasomotor reactivity (CVMR). The unique and novel aspect of this dynamic model is that it is nonlinear and operates in a closed-loop configuration.",
keywords = "Cerebral autoregulation, Cerebral flow autoregulation, Cerebral vasomotor reactivity, Closed-loop modeling, Modeling cerebral hemodynamics, Nonlinear modeling",
author = "Marmarelis, {V. Z.} and Shin, {D. C.} and Orme, {M. E.} and R. Zhang",
year = "2013",
month = "5",
doi = "10.1007/s10439-012-0736-8",
language = "English (US)",
volume = "41",
pages = "1029--1048",
journal = "Annals of Biomedical Engineering",
issn = "0090-6964",
publisher = "Springer Netherlands",
number = "5",

}

TY - JOUR

T1 - Closed-loop dynamic modeling of cerebral hemodynamics

AU - Marmarelis, V. Z.

AU - Shin, D. C.

AU - Orme, M. E.

AU - Zhang, R.

PY - 2013/5

Y1 - 2013/5

N2 - The dynamics of cerebral hemodynamics have been studied extensively because of their fundamental physiological and clinical importance. In particular, the dynamic processes of cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity have attracted broad attention because of their involvement in a host of pathologies and clinical conditions (e.g., hypertension, syncope, stroke, traumatic brain injury, vascular dementia, Alzheimer's disease, mild cognitive impairment etc.). This raises the prospect of useful diagnostic methods being developed on the basis of quantitative models of cerebral hemodynamics, if cerebral vascular dysfunction can be quantified reliably from data collected within practical clinical constraints. This paper presents a modeling method that utilizes beat-to-beat measurements of mean arterial blood pressure, cerebral blood flow velocity and end-tidal CO2 (collected non-invasively under resting conditions) to quantify the dynamics of CFA and cerebral vasomotor reactivity (CVMR). The unique and novel aspect of this dynamic model is that it is nonlinear and operates in a closed-loop configuration.

AB - The dynamics of cerebral hemodynamics have been studied extensively because of their fundamental physiological and clinical importance. In particular, the dynamic processes of cerebral flow autoregulation (CFA) and CO2 vasomotor reactivity have attracted broad attention because of their involvement in a host of pathologies and clinical conditions (e.g., hypertension, syncope, stroke, traumatic brain injury, vascular dementia, Alzheimer's disease, mild cognitive impairment etc.). This raises the prospect of useful diagnostic methods being developed on the basis of quantitative models of cerebral hemodynamics, if cerebral vascular dysfunction can be quantified reliably from data collected within practical clinical constraints. This paper presents a modeling method that utilizes beat-to-beat measurements of mean arterial blood pressure, cerebral blood flow velocity and end-tidal CO2 (collected non-invasively under resting conditions) to quantify the dynamics of CFA and cerebral vasomotor reactivity (CVMR). The unique and novel aspect of this dynamic model is that it is nonlinear and operates in a closed-loop configuration.

KW - Cerebral autoregulation

KW - Cerebral flow autoregulation

KW - Cerebral vasomotor reactivity

KW - Closed-loop modeling

KW - Modeling cerebral hemodynamics

KW - Nonlinear modeling

UR - http://www.scopus.com/inward/record.url?scp=84876460981&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876460981&partnerID=8YFLogxK

U2 - 10.1007/s10439-012-0736-8

DO - 10.1007/s10439-012-0736-8

M3 - Article

C2 - 23292615

AN - SCOPUS:84876460981

VL - 41

SP - 1029

EP - 1048

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

SN - 0090-6964

IS - 5

ER -