Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

Patrick D. Ganzer, Michael J. Darrow, Eric C. Meyers, Bleyda R. Solorzano, Andrea D. Ruiz, Nicole M. Robertson, Katherine S. Adcock, Justin T. James, Han S. Jeong, April M. Becker, Mark P. Goldberg, David T. Pruitt, Seth A. Hays, Michael P. Kilgard, Robert L. Rennaker

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model. Triggering stimulation on the most successful movements is critical to maximize recovery. CLV enhances recovery by strengthening synaptic connectivity from remaining motor networks to the grasping muscles in the forelimb. The benefits of CLV persist long after the end of stimulation because connectivity in critical neural circuits has been restored.

Original languageEnglish (US)
Article numbere32058
JournaleLife
Volume7
DOIs
StatePublished - Mar 13 2018

Fingerprint

Spinal Cord Injuries
Forelimb
Recovery
Rehabilitation
Vagus Nerve Stimulation
Patient rehabilitation
Recovery of Function
Electric Stimulation
Stroke
Networks (circuits)
Muscles
Wounds and Injuries
Plasticity
Muscle
Rats
Feedback

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Ganzer, P. D., Darrow, M. J., Meyers, E. C., Solorzano, B. R., Ruiz, A. D., Robertson, N. M., ... Rennaker, R. L. (2018). Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury. eLife, 7, [e32058]. https://doi.org/10.7554/eLife.32058

Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury. / Ganzer, Patrick D.; Darrow, Michael J.; Meyers, Eric C.; Solorzano, Bleyda R.; Ruiz, Andrea D.; Robertson, Nicole M.; Adcock, Katherine S.; James, Justin T.; Jeong, Han S.; Becker, April M.; Goldberg, Mark P.; Pruitt, David T.; Hays, Seth A.; Kilgard, Michael P.; Rennaker, Robert L.

In: eLife, Vol. 7, e32058, 13.03.2018.

Research output: Contribution to journalArticle

Ganzer, PD, Darrow, MJ, Meyers, EC, Solorzano, BR, Ruiz, AD, Robertson, NM, Adcock, KS, James, JT, Jeong, HS, Becker, AM, Goldberg, MP, Pruitt, DT, Hays, SA, Kilgard, MP & Rennaker, RL 2018, 'Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury', eLife, vol. 7, e32058. https://doi.org/10.7554/eLife.32058
Ganzer PD, Darrow MJ, Meyers EC, Solorzano BR, Ruiz AD, Robertson NM et al. Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury. eLife. 2018 Mar 13;7. e32058. https://doi.org/10.7554/eLife.32058
Ganzer, Patrick D. ; Darrow, Michael J. ; Meyers, Eric C. ; Solorzano, Bleyda R. ; Ruiz, Andrea D. ; Robertson, Nicole M. ; Adcock, Katherine S. ; James, Justin T. ; Jeong, Han S. ; Becker, April M. ; Goldberg, Mark P. ; Pruitt, David T. ; Hays, Seth A. ; Kilgard, Michael P. ; Rennaker, Robert L. / Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury. In: eLife. 2018 ; Vol. 7.
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