Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

Patrick D. Ganzer; Michael J. Darrow; Eric C. Meyers; Bleyda R. Solorzano; Andrea D. Ruiz; Nicole M. Robertson; Katherine S. Adcock; Justin T. James; Han S. Jeong; April M. Becker; Mark P. Goldberg; David T. Pruitt; Seth A. Hays; Michael P. Kilgard; Robert L. Rennaker

doi:10.7554/eLife.32058

Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

Patrick D. Ganzer, Michael J. Darrow, Eric C. Meyers, Bleyda R. Solorzano, Andrea D. Ruiz, Nicole M. Robertson, Katherine S. Adcock, Justin T. James, Han S. Jeong, April M. Becker, Mark P. Goldberg, David T. Pruitt, Seth A. Hays, Michael P. Kilgard, Robert L. Rennaker

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model. Triggering stimulation on the most successful movements is critical to maximize recovery. CLV enhances recovery by strengthening synaptic connectivity from remaining motor networks to the grasping muscles in the forelimb. The benefits of CLV persist long after the end of stimulation because connectivity in critical neural circuits has been restored.

Original language	English (US)
Article number	e32058
Journal	eLife
Volume	7
DOIs	https://doi.org/10.7554/eLife.32058
State	Published - Mar 13 2018

ASJC Scopus subject areas

General Immunology and Microbiology
General Biochemistry, Genetics and Molecular Biology
General Neuroscience

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Ganzer, P. D., Darrow, M. J., Meyers, E. C., Solorzano, B. R., Ruiz, A. D., Robertson, N. M., Adcock, K. S., James, J. T., Jeong, H. S., Becker, A. M., Goldberg, M. P., Pruitt, D. T., Hays, S. A., Kilgard, M. P., & Rennaker, R. L. (2018). Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury. eLife, 7, Article e32058. https://doi.org/10.7554/eLife.32058

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abstract = "Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model. Triggering stimulation on the most successful movements is critical to maximize recovery. CLV enhances recovery by strengthening synaptic connectivity from remaining motor networks to the grasping muscles in the forelimb. The benefits of CLV persist long after the end of stimulation because connectivity in critical neural circuits has been restored.",

author = "Ganzer, {Patrick D.} and Darrow, {Michael J.} and Meyers, {Eric C.} and Solorzano, {Bleyda R.} and Ruiz, {Andrea D.} and Robertson, {Nicole M.} and Adcock, {Katherine S.} and James, {Justin T.} and Jeong, {Han S.} and Becker, {April M.} and Goldberg, {Mark P.} and Pruitt, {David T.} and Hays, {Seth A.} and Kilgard, {Michael P.} and Rennaker, {Robert L.}",

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AU - Ruiz, Andrea D.

AU - Robertson, Nicole M.

AU - Adcock, Katherine S.

AU - James, Justin T.

AU - Jeong, Han S.

AU - Becker, April M.

AU - Goldberg, Mark P.

AU - Pruitt, David T.

AU - Hays, Seth A.

AU - Kilgard, Michael P.

AU - Rennaker, Robert L.

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AB - Recovery from serious neurological injury requires substantial rewiring of neural circuits. Precisely-timed electrical stimulation could be used to restore corrective feedback mechanisms and promote adaptive plasticity after neurological insult, such as spinal cord injury (SCI) or stroke. This study provides the first evidence that closed-loop vagus nerve stimulation (CLV) based on the synaptic eligibility trace leads to dramatic recovery from the most common forms of SCI. The addition of CLV to rehabilitation promoted substantially more recovery of forelimb function compared to rehabilitation alone following chronic unilateral or bilateral cervical SCI in a rat model. Triggering stimulation on the most successful movements is critical to maximize recovery. CLV enhances recovery by strengthening synaptic connectivity from remaining motor networks to the grasping muscles in the forelimb. The benefits of CLV persist long after the end of stimulation because connectivity in critical neural circuits has been restored.

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Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

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ASJC Scopus subject areas

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