Clostridium difficile: Novel insights on an incessantly challenging disease

Sarah Tschudin-Sutter, Andreas F. Widmer, Trish M. Perl

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Purpose of Review: This review comprises recent insights on epidemiology, risk factors, diagnostic approaches, pathophysiologic mechanisms, novel treatment options and prevention strategies of Clostridium difficile infection (CDI). Recent Findings: Incidence of Clostridium difficile continues to rise and hypervirulent subtypes such as polymerase chain reaction (PCR) ribotype 027 and 078 have emerged worldwide. Children and postpartum women are increasingly recognized as being at risk for development of CDI and community-associated infection is no longer rare. PCR technology may replace complicated two-step test algorithms in the future, because it is rapid, sensitive and specific. Pathophysiological studies have provided evidence that either one of the two exotoxins A and B is important in conferring virulence-the role of binary toxin requires further investigation. Proton pump inhibitors are now established as important risk factors for acquiring, complicating CDI, and developing recurrences. Fidaxomycin, monoclonal antibodies and intestinal microbiota transplantation are promising new treatment options, especially regarding prevention of recurrent disease. Future prevention strategies involve vaccination and novel insights on reservoirs for ongoing transmission, including the food chain. Summary: Important advances in research on CDI include novel diagnostic approaches, better understanding of the underlying pathophysiological mechanisms of disease and the development of new approaches to treatment.

Original languageEnglish (US)
Pages (from-to)405-411
Number of pages7
JournalCurrent Opinion in Infectious Diseases
Volume25
Issue number4
DOIs
StatePublished - Aug 1 2012

Fingerprint

Clostridium difficile
Clostridium Infections
Ribotyping
Exotoxins
Polymerase Chain Reaction
Food Chain
Proton Pump Inhibitors
Exercise Test
Postpartum Period
Virulence
Vaccination
Epidemiology
Therapeutics
Transplantation
Monoclonal Antibodies
Technology
Recurrence
Incidence
Infection
Research

Keywords

  • Clostridium difficile
  • diagnostic assays
  • epidemiology
  • polymerase chain reaction ribotype 027

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Clostridium difficile : Novel insights on an incessantly challenging disease. / Tschudin-Sutter, Sarah; Widmer, Andreas F.; Perl, Trish M.

In: Current Opinion in Infectious Diseases, Vol. 25, No. 4, 01.08.2012, p. 405-411.

Research output: Contribution to journalReview article

Tschudin-Sutter, Sarah ; Widmer, Andreas F. ; Perl, Trish M. / Clostridium difficile : Novel insights on an incessantly challenging disease. In: Current Opinion in Infectious Diseases. 2012 ; Vol. 25, No. 4. pp. 405-411.
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