Cluster analysis of self-monitoring blood glucose assessments in clinical islet cell transplantation for type 1 diabetes

Morihito Takita, Shinichi Matsumoto, Hirofumi Noguchi, Masayuki Shimoda, Daisuke Chujo, Takeshi Itoh, Koji Sugimoto, Jeffery A. SoRelle, Nicholas Onaca, Bashoo Naziruddin, Marlon F. Levy

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

OBJECTIVE-Cluster analysis was performed on the results of self-monitoring of blood glucose (SMBG) to discriminate islet graft function after islet cell transplantation (ICT) in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS-Eleven islet recipients were included in this study. The patients visited our clinic monthly after ICT and provided blood samples for fasting C-peptide (n = 270), which were used to evaluate islet graft function. They also provided their SMBG data through an automatic data collection system. The SMBG data for 3 days immediately before each clinic visit were evaluated using the following assessments: M value, mean amplitude of glycemic excursions, J index, index of glycemic control, average daily risk range, and glycemic risk assessment diabetes equation. The cluster analysis was performed for both SMBG assessments and samples. Multivariate logistic regression analysis was used to evaluate the clusters of SMBG for assessing islet graft function. RESULTS-Analysis for SMBG assessments revealed five types of clusters, which showed similar patterns according to functional or dysfunctional islet graft phase. Two clusters, the euglycemia cluster (P < 0.001) and the hypoglycemia cluster (P = 0.001), were significant factors in the logistic model for islet graft function. The SMBG clusters had significant correlations with clinical graft indexes (P < 0.001). CONCLUSIONS-Cluster analysis of SMBG data as part of an automated data quality system could allow discrimination of islet graft dysfunction after ICT. This approach should be considered for islet recipients.

Original languageEnglish (US)
Pages (from-to)1799-1803
Number of pages5
JournalDiabetes care
Volume34
Issue number8
DOIs
StatePublished - Aug 2011
Externally publishedYes

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