Clusterin and DNA repair: A new function in cancer for a key player in apoptosis and cell cycle control

B. Shannan, M. Seifert, D. A. Boothman, W. Tilgen, J. Reichrath

Research output: Contribution to journalReview articlepeer-review

61 Scopus citations

Abstract

The glycoprotein clusterin (CLU), has two known isoforms generated in human cells. A nuclear form of CLU protein (nCLU) is pro-apoptotic, while a secretory form (sCLU) is pro-survival. Both forms are implicated in various cell functions, including DNA repair, cell cycle regulation, and apoptotic cell death. CLU expression has been associated with tumorigenesis and the progression of various malignancies. In response to DNA damage, cell survival can be enhanced by activation of DNA repair mechanisms, while simultaneously stimulating energy-expensive cell cycle checkpoints that delay the cell cycle progression to allow more time for DNA repair. This review summarizes our current understanding of the role of clusterin in DNA repair, apoptosis, and cell cycle control and the relevance.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalJournal of Molecular Histology
Volume37
Issue number5-7
DOIs
StatePublished - Sep 1 2006

Keywords

  • Apoptosis
  • Cell cycle control
  • Clusterin
  • DNA repair
  • Double strand break

ASJC Scopus subject areas

  • Histology
  • Physiology
  • Cell Biology

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