CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation

Ron Bumeister, Carine Rosse, Anthony Anselmo, Jacques Camonis, Michael A. White

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Neuronal precursor cells have the capacity to engage the Raf-MEK-ERK signal module to drive either of two distinctly different regulatory programs, proliferation and differentiation. This is, at least in part, a consequence of stimulus-specific shaping of the kinase cascade response. For example, the mitogen EGF induces a transient ERK activation, whereas the neurotrophin NGF induces prolonged ERK activation [1]. Here we define a novel component of the regulatory machinery contributing to the selective integration of MAP kinase signaling with discrete biological responses. We show that the scaffold/adaptor protein CNK2/MAGUIN-1 is required for NGF- but not EGF-induced ERK activation. In addition, CNK2 makes a separate, essential contribution to the coupling of NGF signaling to membrane/cytoskeletal remodeling. We propose that CNK2 integrates multiple regulatory pathways that must function in concert to drive an appropriate biological response to external stimuli.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
JournalCurrent Biology
Volume14
Issue number5
DOIs
StatePublished - Mar 9 2004

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Nerve Growth Factor
mitogen-activated protein kinase
cell differentiation
Cell Differentiation
Chemical activation
Epidermal Growth Factor
Phosphotransferases
Mitogen-Activated Protein Kinase Kinases
Nerve Growth Factors
Mitogens
Scaffolds
Machinery
neurotrophins
Membranes
phosphotransferases (kinases)
Proteins
proteins
cells

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation. / Bumeister, Ron; Rosse, Carine; Anselmo, Anthony; Camonis, Jacques; White, Michael A.

In: Current Biology, Vol. 14, No. 5, 09.03.2004, p. 439-445.

Research output: Contribution to journalArticle

Bumeister, Ron ; Rosse, Carine ; Anselmo, Anthony ; Camonis, Jacques ; White, Michael A. / CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation. In: Current Biology. 2004 ; Vol. 14, No. 5. pp. 439-445.
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