@article{7035a6a4c5794acb83fe76b7f42e10ab,
title = "CNS critical periods: Implications for dystonia and other neurodevelopmental disorders",
abstract = "Critical periods are discrete developmental stages when the nervous system is especially sensitive to stimuli that facilitate circuit maturation. The distinctive landscapes assumed by the developing CNS create analogous periods of susceptibility to pathogenic insults and responsiveness to therapy. Here, we review critical periods in nervous system development and disease, with an emphasis on the neurodevelopmental disorder DYT1 dystonia. We highlight clinical and laboratory observations supporting the existence of a critical period during which the DYT1 mutation is uniquely harmful, and the implications for future therapeutic development.",
author = "Jay Li and Sumin Kim and Pappas, {Samuel S.} and Dauer, {William T.}",
note = "Funding Information: This project was supported by NIH grants R01 NS109227, F31 NS113433, T32 GM007863, and T32 GM007315, and Tyler's Hope for a Dystonia Cure Foundation. Funding Information: This project was supported by NIH grants R01 NS109227, F31 NS113433, T32 GM007863, and T32 GM007315, and Tyler{\textquoteright}s Hope for a Dystonia Cure Foundation. Publisher Copyright: {\textcopyright} 2021, Li et al. This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = feb,
day = "22",
doi = "10.1172/jci.insight.142483",
language = "English (US)",
volume = "6",
journal = "JCI insight",
issn = "2379-3708",
publisher = "The American Society for Clinical Investigation",
number = "4",
}