CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10

Ian H. Guldner; Qingfei Wang; Lin Yang; Samantha M. Golomb; Zhuo Zhao; Jacqueline A. Lopez; Abigail Brunory; Erin N. Howe; Yizhe Zhang; Bhavana Palakurthi; Martin Barron; Hongyu Gao; Xiaoling Xuei; Yunlong Liu; Jun Li; Danny Z. Chen; Gary E. Landreth; Siyuan Zhang

doi:10.1016/j.cell.2020.09.064

CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10

Ian H. Guldner, Qingfei Wang, Lin Yang, Samantha M. Golomb, Zhuo Zhao, Jacqueline A. Lopez, Abigail Brunory, Erin N. Howe, Yizhe Zhang, Bhavana Palakurthi, Martin Barron, Hongyu Gao, Xiaoling Xuei, Yunlong Liu, Jun Li, Danny Z. Chen, Gary E. Landreth, Siyuan Zhang

Research output: Contribution to journal › Article › peer-review

75 Scopus citations

Abstract

A multimodal investigation into the tumor microenvironment of brain metastases in mouse models demonstrates the central role of CNS-resident myeloid populations in creating an immunosuppressive pro-metastatic microenvironment.

Original language	English (US)
Pages (from-to)	1234-1248.e25
Journal	Cell
Volume	183
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2020.09.064
State	Published - Nov 25 2020
Externally published	Yes

Keywords

Brain metastasis
T cells
bone marrow-derived myeloid cells
brain immunity
cancer immunology
immune suppression
immune therapy
metastatic niche
microglia
tumor microenvironment

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2020.09.064

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Guldner, I. H., Wang, Q., Yang, L., Golomb, S. M., Zhao, Z., Lopez, J. A., Brunory, A., Howe, E. N., Zhang, Y., Palakurthi, B., Barron, M., Gao, H., Xuei, X., Liu, Y., Li, J., Chen, D. Z., Landreth, G. E., & Zhang, S. (2020). CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10. Cell, 183(5), 1234-1248.e25. https://doi.org/10.1016/j.cell.2020.09.064

Guldner, IH, Wang, Q, Yang, L, Golomb, SM, Zhao, Z, Lopez, JA, Brunory, A, Howe, EN, Zhang, Y, Palakurthi, B, Barron, M, Gao, H, Xuei, X, Liu, Y, Li, J, Chen, DZ, Landreth, GE & Zhang, S 2020, 'CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10', Cell, vol. 183, no. 5, pp. 1234-1248.e25. https://doi.org/10.1016/j.cell.2020.09.064

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title = "CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10",

abstract = "A multimodal investigation into the tumor microenvironment of brain metastases in mouse models demonstrates the central role of CNS-resident myeloid populations in creating an immunosuppressive pro-metastatic microenvironment.",

keywords = "Brain metastasis, T cells, bone marrow-derived myeloid cells, brain immunity, cancer immunology, immune suppression, immune therapy, metastatic niche, microglia, tumor microenvironment",

author = "Guldner, {Ian H.} and Qingfei Wang and Lin Yang and Golomb, {Samantha M.} and Zhuo Zhao and Lopez, {Jacqueline A.} and Abigail Brunory and Howe, {Erin N.} and Yizhe Zhang and Bhavana Palakurthi and Martin Barron and Hongyu Gao and Xiaoling Xuei and Yunlong Liu and Jun Li and Chen, {Danny Z.} and Landreth, {Gary E.} and Siyuan Zhang",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = nov,

day = "25",

doi = "10.1016/j.cell.2020.09.064",

language = "English (US)",

volume = "183",

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journal = "Cell",

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T1 - CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10

AU - Guldner, Ian H.

AU - Wang, Qingfei

AU - Yang, Lin

AU - Golomb, Samantha M.

AU - Zhao, Zhuo

AU - Lopez, Jacqueline A.

AU - Brunory, Abigail

AU - Howe, Erin N.

AU - Zhang, Yizhe

AU - Palakurthi, Bhavana

AU - Barron, Martin

AU - Gao, Hongyu

AU - Xuei, Xiaoling

AU - Liu, Yunlong

AU - Li, Jun

AU - Chen, Danny Z.

AU - Landreth, Gary E.

AU - Zhang, Siyuan

PY - 2020/11/25

Y1 - 2020/11/25

N2 - A multimodal investigation into the tumor microenvironment of brain metastases in mouse models demonstrates the central role of CNS-resident myeloid populations in creating an immunosuppressive pro-metastatic microenvironment.

AB - A multimodal investigation into the tumor microenvironment of brain metastases in mouse models demonstrates the central role of CNS-resident myeloid populations in creating an immunosuppressive pro-metastatic microenvironment.

KW - Brain metastasis

KW - T cells

KW - bone marrow-derived myeloid cells

KW - brain immunity

KW - cancer immunology

KW - immune suppression

KW - immune therapy

KW - metastatic niche

KW - microglia

KW - tumor microenvironment

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JO - Cell

JF - Cell

IS - 5

ER -

CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10

Abstract

Keywords

ASJC Scopus subject areas

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