CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10

Ian H. Guldner, Qingfei Wang, Lin Yang, Samantha M. Golomb, Zhuo Zhao, Jacqueline A. Lopez, Abigail Brunory, Erin N. Howe, Yizhe Zhang, Bhavana Palakurthi, Martin Barron, Hongyu Gao, Xiaoling Xuei, Yunlong Liu, Jun Li, Danny Z. Chen, Gary E. Landreth, Siyuan Zhang

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

A multimodal investigation into the tumor microenvironment of brain metastases in mouse models demonstrates the central role of CNS-resident myeloid populations in creating an immunosuppressive pro-metastatic microenvironment.

Original languageEnglish (US)
Pages (from-to)1234-1248.e25
JournalCell
Volume183
Issue number5
DOIs
StatePublished - Nov 25 2020
Externally publishedYes

Keywords

  • bone marrow-derived myeloid cells
  • brain immunity
  • Brain metastasis
  • cancer immunology
  • immune suppression
  • immune therapy
  • metastatic niche
  • microglia
  • T cells
  • tumor microenvironment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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