Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex

Claire Amadou, Ruth M. Younger, Sarah Sims, Lucy H. Matthews, Jane Rogers, Attila Kumánovics, Andreas Ziegler, Stephan Beck, Kirsten Fischer Lindahl

Research output: Contribution to journalArticle

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Abstract

We report the 897 kb sequence of a cluster of olfactory receptor (OR) genes located at the distal end of the major histocompatibility complex (MHC) class I region on mouse chromosome 17 of strain 129/SvJ (H2bc). With additional information from the mouse genome draft sequence, we identified 59 OR loci (∼20% pseudogenes) in contrast to only 25 OR loci (∼50% pseudogenes) in the corresponding centromeric OR cluster that is part of the 'extended MHC class I region' on human chromosome 6. Comparative analysis leads to three major observations: (i) most of the OR subfamilies have evolved independently in the two species, expanding more in the mouse, and resulting in co-orthologs-subfamilies of highly similar paralogs that keep orthologous relationships with their human counterparts; (ii) three of the mouse OR subfamilies have no orthologs in humans; and (iii) MHC class I loci are interspersed in the OR cluster in mouse but not in human, and were subjected to co-duplication with OR genes. Screening of our sequence against the available sequences of other strains/haplotypes revealed that most of the OR loci are polymorphic and that the number of OR loci may vary among strains/haplotypes. Our findings that MHC-linked OR loci share duplication with MHC class I loci, have duplicated extensively and are polymorphic revives questions about potential reciprocal influences acting on the dynamics and evolution of the H2 region and the H2-linked OR loci.

Original languageEnglish (US)
Pages (from-to)3025-3040
Number of pages16
JournalHuman Molecular Genetics
Volume12
Issue number22
DOIs
StatePublished - Nov 15 2003

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Odorant Receptors
MHC Class I Genes
Major Histocompatibility Complex
Pseudogenes
Haplotypes
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 6
Human Chromosomes
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Amadou, C., Younger, R. M., Sims, S., Matthews, L. H., Rogers, J., Kumánovics, A., ... Lindahl, K. F. (2003). Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex. Human Molecular Genetics, 12(22), 3025-3040. https://doi.org/10.1093/hmg/ddg317

Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex. / Amadou, Claire; Younger, Ruth M.; Sims, Sarah; Matthews, Lucy H.; Rogers, Jane; Kumánovics, Attila; Ziegler, Andreas; Beck, Stephan; Lindahl, Kirsten Fischer.

In: Human Molecular Genetics, Vol. 12, No. 22, 15.11.2003, p. 3025-3040.

Research output: Contribution to journalArticle

Amadou, C, Younger, RM, Sims, S, Matthews, LH, Rogers, J, Kumánovics, A, Ziegler, A, Beck, S & Lindahl, KF 2003, 'Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex', Human Molecular Genetics, vol. 12, no. 22, pp. 3025-3040. https://doi.org/10.1093/hmg/ddg317
Amadou C, Younger RM, Sims S, Matthews LH, Rogers J, Kumánovics A et al. Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex. Human Molecular Genetics. 2003 Nov 15;12(22):3025-3040. https://doi.org/10.1093/hmg/ddg317
Amadou, Claire ; Younger, Ruth M. ; Sims, Sarah ; Matthews, Lucy H. ; Rogers, Jane ; Kumánovics, Attila ; Ziegler, Andreas ; Beck, Stephan ; Lindahl, Kirsten Fischer. / Co-duplication of olfactory receptor and MHC class I genes in the mouse major histocompatibility complex. In: Human Molecular Genetics. 2003 ; Vol. 12, No. 22. pp. 3025-3040.
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