Cocaine like effects of intravenous procaine in cocaine addicts

Bryon Adinoff, Kathleen Brady, Susan Sonne, Robert F. Mirabella, Charles H. Kellner

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Pharmacological treatments that alter dopaminergic functioning have not lessened cocaine use in addicted patients. Non-dopaminergic mechanisms may therefore be important in the chronic use of cocaine. Procaine, like cocaine, is a local anesthetic, but has only 1% of cocaine's affinity for the dopamine reuptake receptor. In order to assess the subjective effects procaine and its similarity to cocaine, we administered procaine to nine cocaine-dependent subjects. Patients 2-3 weeks abstinent were administered placebo, low dose procaine (0.46 mg/kg), and high dose procaine (1.84 mg/kg procaine) over a single 2-hour session. Patients were assessed for craving and similarity to cocaine experience and were administered the Symptom Checklist 90 Revised (SCL90R). High dose procaine was identified as similar to cocaine and induced significant cocaine craving. High dose procaine also induced significant elevations in somatization, obsessive-compulsive symptoms, phobic anxiety, interpersonal sensitivity anxiety, positive symptoms and global severity (from the the SCL90R). Our findings suggest that procaine shares subjective effects similar to cocaine, despite a much lower affinity for the dopamine reuptake receptor. Procaine may be a useful tool to explore non-dopaminergic mechanisms of cocaine's reinforcing and addictive properties.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalAddiction Biology
Volume3
Issue number2
DOIs
StatePublished - 1998

Fingerprint

Procaine
Cocaine
Dopamine Receptors
Checklist
Anxiety
Local Anesthetics
Placebos
Pharmacology

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Adinoff, B., Brady, K., Sonne, S., Mirabella, R. F., & Kellner, C. H. (1998). Cocaine like effects of intravenous procaine in cocaine addicts. Addiction Biology, 3(2), 189-196. https://doi.org/10.1080/13556219872245

Cocaine like effects of intravenous procaine in cocaine addicts. / Adinoff, Bryon; Brady, Kathleen; Sonne, Susan; Mirabella, Robert F.; Kellner, Charles H.

In: Addiction Biology, Vol. 3, No. 2, 1998, p. 189-196.

Research output: Contribution to journalArticle

Adinoff, B, Brady, K, Sonne, S, Mirabella, RF & Kellner, CH 1998, 'Cocaine like effects of intravenous procaine in cocaine addicts', Addiction Biology, vol. 3, no. 2, pp. 189-196. https://doi.org/10.1080/13556219872245
Adinoff, Bryon ; Brady, Kathleen ; Sonne, Susan ; Mirabella, Robert F. ; Kellner, Charles H. / Cocaine like effects of intravenous procaine in cocaine addicts. In: Addiction Biology. 1998 ; Vol. 3, No. 2. pp. 189-196.
@article{a1bacf806b6940d18c40a684a152ab1f,
title = "Cocaine like effects of intravenous procaine in cocaine addicts",
abstract = "Pharmacological treatments that alter dopaminergic functioning have not lessened cocaine use in addicted patients. Non-dopaminergic mechanisms may therefore be important in the chronic use of cocaine. Procaine, like cocaine, is a local anesthetic, but has only 1{\%} of cocaine's affinity for the dopamine reuptake receptor. In order to assess the subjective effects procaine and its similarity to cocaine, we administered procaine to nine cocaine-dependent subjects. Patients 2-3 weeks abstinent were administered placebo, low dose procaine (0.46 mg/kg), and high dose procaine (1.84 mg/kg procaine) over a single 2-hour session. Patients were assessed for craving and similarity to cocaine experience and were administered the Symptom Checklist 90 Revised (SCL90R). High dose procaine was identified as similar to cocaine and induced significant cocaine craving. High dose procaine also induced significant elevations in somatization, obsessive-compulsive symptoms, phobic anxiety, interpersonal sensitivity anxiety, positive symptoms and global severity (from the the SCL90R). Our findings suggest that procaine shares subjective effects similar to cocaine, despite a much lower affinity for the dopamine reuptake receptor. Procaine may be a useful tool to explore non-dopaminergic mechanisms of cocaine's reinforcing and addictive properties.",
author = "Bryon Adinoff and Kathleen Brady and Susan Sonne and Mirabella, {Robert F.} and Kellner, {Charles H.}",
year = "1998",
doi = "10.1080/13556219872245",
language = "English (US)",
volume = "3",
pages = "189--196",
journal = "Addiction Biology",
issn = "1355-6215",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Cocaine like effects of intravenous procaine in cocaine addicts

AU - Adinoff, Bryon

AU - Brady, Kathleen

AU - Sonne, Susan

AU - Mirabella, Robert F.

AU - Kellner, Charles H.

PY - 1998

Y1 - 1998

N2 - Pharmacological treatments that alter dopaminergic functioning have not lessened cocaine use in addicted patients. Non-dopaminergic mechanisms may therefore be important in the chronic use of cocaine. Procaine, like cocaine, is a local anesthetic, but has only 1% of cocaine's affinity for the dopamine reuptake receptor. In order to assess the subjective effects procaine and its similarity to cocaine, we administered procaine to nine cocaine-dependent subjects. Patients 2-3 weeks abstinent were administered placebo, low dose procaine (0.46 mg/kg), and high dose procaine (1.84 mg/kg procaine) over a single 2-hour session. Patients were assessed for craving and similarity to cocaine experience and were administered the Symptom Checklist 90 Revised (SCL90R). High dose procaine was identified as similar to cocaine and induced significant cocaine craving. High dose procaine also induced significant elevations in somatization, obsessive-compulsive symptoms, phobic anxiety, interpersonal sensitivity anxiety, positive symptoms and global severity (from the the SCL90R). Our findings suggest that procaine shares subjective effects similar to cocaine, despite a much lower affinity for the dopamine reuptake receptor. Procaine may be a useful tool to explore non-dopaminergic mechanisms of cocaine's reinforcing and addictive properties.

AB - Pharmacological treatments that alter dopaminergic functioning have not lessened cocaine use in addicted patients. Non-dopaminergic mechanisms may therefore be important in the chronic use of cocaine. Procaine, like cocaine, is a local anesthetic, but has only 1% of cocaine's affinity for the dopamine reuptake receptor. In order to assess the subjective effects procaine and its similarity to cocaine, we administered procaine to nine cocaine-dependent subjects. Patients 2-3 weeks abstinent were administered placebo, low dose procaine (0.46 mg/kg), and high dose procaine (1.84 mg/kg procaine) over a single 2-hour session. Patients were assessed for craving and similarity to cocaine experience and were administered the Symptom Checklist 90 Revised (SCL90R). High dose procaine was identified as similar to cocaine and induced significant cocaine craving. High dose procaine also induced significant elevations in somatization, obsessive-compulsive symptoms, phobic anxiety, interpersonal sensitivity anxiety, positive symptoms and global severity (from the the SCL90R). Our findings suggest that procaine shares subjective effects similar to cocaine, despite a much lower affinity for the dopamine reuptake receptor. Procaine may be a useful tool to explore non-dopaminergic mechanisms of cocaine's reinforcing and addictive properties.

UR - http://www.scopus.com/inward/record.url?scp=0031953363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031953363&partnerID=8YFLogxK

U2 - 10.1080/13556219872245

DO - 10.1080/13556219872245

M3 - Article

C2 - 26734823

AN - SCOPUS:0031953363

VL - 3

SP - 189

EP - 196

JO - Addiction Biology

JF - Addiction Biology

SN - 1355-6215

IS - 2

ER -