Coexistent holoprosencephaly and Chiari II malformation

Nancy Rollins, Jeanne Joglar, Jeffery Perlman

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Chiari H malformations and holoprosencephaly have been considered to be brain malformations that differ with respect to teratogenic insult, embryologic mechanism, and morphology. We herein describe coexistent Chiari II malformation and holoprosencephaly that occurred in a viable infant. A review of the literature regarding Chiari II malformations and holoprosencephaly suggests that a disturbance to the mesenchyme in early embryologic life may be the cause of both malformations.

Original languageEnglish (US)
Pages (from-to)1678-1681
Number of pages4
JournalAmerican Journal of Neuroradiology
Issue number9
StatePublished - Nov 4 1999

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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