Coexposure to Borrelia burgdorferi and Babesia microti does not worsen the long-term outcome of Lyme disease

Thomas J. Wang, Matthew H. Liang, Oliver Sangha, Charlotte B. Phillips, Robert A. Lew, Elizabeth A. Wright, Victor Berardi, Anne H. Fossel, Nancy A. Shadick

Research output: Contribution to journalArticle

Abstract

Previous studies suggest that concurrent Lyme disease and babesiosis produce a more sever illness than either disease alone. The majority of babesiosis infections, however, are subclinical. Our objective was to characterize on the basis of a total-population survey of Nantucket Island, Massachusetts, whether coexposure to Lyme disease and babesiosis causes more severe illness or poorer long-term outcomes than Lyme disease alone. In this retrospective cohort study, residents indicating a history of Lyme disease were compared with randomly selected population controls on a standardized medical history, blinded physical examination, and serological studies for Borrelia burgdorferi and Babesia microti. Serological evidence of exposure to babesiosis was not associated with increased severity of acute Lyme disease. The groups did not differ with regard to the prevalence of constitutional, musculoskeletal, or neurological symptoms a mean of 6 years after acute Lyme disease. Prior Lyme disease and serological exposure to B. microti are not associated with poorer long-term outcomes or more persistent symptoms Lyme disease alone.

Original languageEnglish (US)
Pages (from-to)1149-1154
Number of pages6
JournalClinical Infectious Diseases
Volume31
Issue number5
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Coexposure to Borrelia burgdorferi and Babesia microti does not worsen the long-term outcome of Lyme disease'. Together they form a unique fingerprint.

  • Cite this

    Wang, T. J., Liang, M. H., Sangha, O., Phillips, C. B., Lew, R. A., Wright, E. A., Berardi, V., Fossel, A. H., & Shadick, N. A. (2000). Coexposure to Borrelia burgdorferi and Babesia microti does not worsen the long-term outcome of Lyme disease. Clinical Infectious Diseases, 31(5), 1149-1154. https://doi.org/10.1086/317465