Coexpression of myogenic functions in L6 rat × T984 mouse myoblast hybrids

Woodring E. Wright, F. Gros

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

L6 rat myoblasts differ from T984 mouse myoblasts in the expression of several myogenic functions. Simple hybrids between these myogenic lines contained mostly chromosomes and expressed the mouse phenotype. Hybrids containing an approximately balanced set of chromosomes from each parent were constructed by fusing tetraploid L6 cells to T984 myoblasts. These hybrids were allowed to differentiate and their expression of myogenic proteins was compared to the parental phenotypes. The synthesis of creatine phosphokinase isoenzymes is codominantly expressed in the hybrid cells. Myosin light chain synthesis and the levels of acetylcholine receptor are either regulated by the mouse genome or are codominantly expressed.

Original languageEnglish (US)
Pages (from-to)236-240
Number of pages5
JournalDevelopmental Biology
Volume86
Issue number1
DOIs
StatePublished - Aug 1981

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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