Abstract
L6 rat myoblasts differ from T984 mouse myoblasts in the expression of several myogenic functions. Simple hybrids between these myogenic lines contained mostly chromosomes and expressed the mouse phenotype. Hybrids containing an approximately balanced set of chromosomes from each parent were constructed by fusing tetraploid L6 cells to T984 myoblasts. These hybrids were allowed to differentiate and their expression of myogenic proteins was compared to the parental phenotypes. The synthesis of creatine phosphokinase isoenzymes is codominantly expressed in the hybrid cells. Myosin light chain synthesis and the levels of acetylcholine receptor are either regulated by the mouse genome or are codominantly expressed.
Original language | English (US) |
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Pages (from-to) | 236-240 |
Number of pages | 5 |
Journal | Developmental Biology |
Volume | 86 |
Issue number | 1 |
DOIs | |
State | Published - Aug 1981 |
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology