Cognitive dysfunction after central pontine myelinolysis

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Central pontine myelinolysis (CPM) is a rare but increasingly recognized neurological disorder associated with a lesion of the central portion of the basis pontis and characterized by altered level of consciousness, seizures, pseudobulbar palsy, dysphagia, and quadriparesis. Until the advent of computerized tomography, CPM was considered fatal and discovered only at post-mortem. The case is reported of a 61-year-old, high-functioning, non-alcoholic man who developed CPM after liver transplantation. Neuropsychological evaluation documented many expected motoric deficits. More unforeseen was this patient's lingering amnestic syndrome and global lowering of many 'higher' cognitive processes, e.g. intelligence, reasoning, concentration, etc. The role of the brainstem in 'higher' cognitive functions is considered through four mechanisms: the reticular activating system, disruption of neocortical-ponto-cerebellar networks, the preliminary processing model, and through interruption of neurotransmitter pathways.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalNeurocase
Volume4
Issue number3
DOIs
StatePublished - 1998

Fingerprint

Central Pontine Myelinolysis
Pseudobulbar Palsy
Consciousness Disorders
Quadriplegia
Deglutition Disorders
Nervous System Diseases
Intelligence
Liver Transplantation
Cognition
Brain Stem
Neurotransmitter Agents
Seizures
Tomography
Cognitive Dysfunction
Transplantation
Evaluation
Cognitive Function
Consciousness
Neurological Disorders
Syndrome

Keywords

  • Brainstem dysfunction
  • Central pontine myelinolysis
  • Cognitive disorders
  • Pons

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Psychology(all)

Cite this

Cognitive dysfunction after central pontine myelinolysis. / Ruchinskas, Robert.

In: Neurocase, Vol. 4, No. 3, 1998, p. 173-179.

Research output: Contribution to journalArticle

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