Cognitive function and regional cerebral blood flow in partial seizures

R. W. Homan, R. G. Paulman, M. D. Devous, P. Walker, L. W. Jennings, F. J. Bonte

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Patients with partial seizures have cognitive function impairments that have been attributed to the toxic side effects of anticonvulsants and structural cerebral damage. However, even when these factors are absent, neuropsychological (NP) deficits have been demonstrated, although of milder degree than in structurally brain-damaged patients. Assessment of cerebral metabolism using positron emission tomography and cerebral blood flow with single photon emission computed tomography (SPECT) reveals focal physiologic deficits in structurally normal areas. Using both SPECT and NP assessment with the Halstead-Reitan Battery, we evaluated 50 patients with partial seizures. Comparison of the location of visually identified regional cerebral blood flow (rCBF) deficits in these patients with the location of the NP deficits revealed a significant correlation. Additional analyses indicated that rCBF quantification in visually identified areas of hypoperfusion was significantly lower than in 'normal' areas and that quantified NP variables significantly discriminated patients with and without visual rCBF deficits in temporal and frontal brain regions.

Original languageEnglish (US)
Pages (from-to)964-970
Number of pages7
JournalArchives of Neurology
Volume46
Issue number9
StatePublished - 1989

Fingerprint

Cerebrovascular Circulation
Regional Blood Flow
Cognition
Seizures
Single-Photon Emission-Computed Tomography
Poisons
Brain
Positron-Emission Tomography
Anticonvulsants
Cognitive Function
Regional Cerebral Blood Flow

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Homan, R. W., Paulman, R. G., Devous, M. D., Walker, P., Jennings, L. W., & Bonte, F. J. (1989). Cognitive function and regional cerebral blood flow in partial seizures. Archives of Neurology, 46(9), 964-970.

Cognitive function and regional cerebral blood flow in partial seizures. / Homan, R. W.; Paulman, R. G.; Devous, M. D.; Walker, P.; Jennings, L. W.; Bonte, F. J.

In: Archives of Neurology, Vol. 46, No. 9, 1989, p. 964-970.

Research output: Contribution to journalArticle

Homan, RW, Paulman, RG, Devous, MD, Walker, P, Jennings, LW & Bonte, FJ 1989, 'Cognitive function and regional cerebral blood flow in partial seizures', Archives of Neurology, vol. 46, no. 9, pp. 964-970.
Homan RW, Paulman RG, Devous MD, Walker P, Jennings LW, Bonte FJ. Cognitive function and regional cerebral blood flow in partial seizures. Archives of Neurology. 1989;46(9):964-970.
Homan, R. W. ; Paulman, R. G. ; Devous, M. D. ; Walker, P. ; Jennings, L. W. ; Bonte, F. J. / Cognitive function and regional cerebral blood flow in partial seizures. In: Archives of Neurology. 1989 ; Vol. 46, No. 9. pp. 964-970.
@article{bca6731f1b364f10bb73db393124920d,
title = "Cognitive function and regional cerebral blood flow in partial seizures",
abstract = "Patients with partial seizures have cognitive function impairments that have been attributed to the toxic side effects of anticonvulsants and structural cerebral damage. However, even when these factors are absent, neuropsychological (NP) deficits have been demonstrated, although of milder degree than in structurally brain-damaged patients. Assessment of cerebral metabolism using positron emission tomography and cerebral blood flow with single photon emission computed tomography (SPECT) reveals focal physiologic deficits in structurally normal areas. Using both SPECT and NP assessment with the Halstead-Reitan Battery, we evaluated 50 patients with partial seizures. Comparison of the location of visually identified regional cerebral blood flow (rCBF) deficits in these patients with the location of the NP deficits revealed a significant correlation. Additional analyses indicated that rCBF quantification in visually identified areas of hypoperfusion was significantly lower than in 'normal' areas and that quantified NP variables significantly discriminated patients with and without visual rCBF deficits in temporal and frontal brain regions.",
author = "Homan, {R. W.} and Paulman, {R. G.} and Devous, {M. D.} and P. Walker and Jennings, {L. W.} and Bonte, {F. J.}",
year = "1989",
language = "English (US)",
volume = "46",
pages = "964--970",
journal = "Archives of Neurology",
issn = "0003-9942",
publisher = "American Medical Association",
number = "9",

}

TY - JOUR

T1 - Cognitive function and regional cerebral blood flow in partial seizures

AU - Homan, R. W.

AU - Paulman, R. G.

AU - Devous, M. D.

AU - Walker, P.

AU - Jennings, L. W.

AU - Bonte, F. J.

PY - 1989

Y1 - 1989

N2 - Patients with partial seizures have cognitive function impairments that have been attributed to the toxic side effects of anticonvulsants and structural cerebral damage. However, even when these factors are absent, neuropsychological (NP) deficits have been demonstrated, although of milder degree than in structurally brain-damaged patients. Assessment of cerebral metabolism using positron emission tomography and cerebral blood flow with single photon emission computed tomography (SPECT) reveals focal physiologic deficits in structurally normal areas. Using both SPECT and NP assessment with the Halstead-Reitan Battery, we evaluated 50 patients with partial seizures. Comparison of the location of visually identified regional cerebral blood flow (rCBF) deficits in these patients with the location of the NP deficits revealed a significant correlation. Additional analyses indicated that rCBF quantification in visually identified areas of hypoperfusion was significantly lower than in 'normal' areas and that quantified NP variables significantly discriminated patients with and without visual rCBF deficits in temporal and frontal brain regions.

AB - Patients with partial seizures have cognitive function impairments that have been attributed to the toxic side effects of anticonvulsants and structural cerebral damage. However, even when these factors are absent, neuropsychological (NP) deficits have been demonstrated, although of milder degree than in structurally brain-damaged patients. Assessment of cerebral metabolism using positron emission tomography and cerebral blood flow with single photon emission computed tomography (SPECT) reveals focal physiologic deficits in structurally normal areas. Using both SPECT and NP assessment with the Halstead-Reitan Battery, we evaluated 50 patients with partial seizures. Comparison of the location of visually identified regional cerebral blood flow (rCBF) deficits in these patients with the location of the NP deficits revealed a significant correlation. Additional analyses indicated that rCBF quantification in visually identified areas of hypoperfusion was significantly lower than in 'normal' areas and that quantified NP variables significantly discriminated patients with and without visual rCBF deficits in temporal and frontal brain regions.

UR - http://www.scopus.com/inward/record.url?scp=0024464003&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024464003&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 964

EP - 970

JO - Archives of Neurology

JF - Archives of Neurology

SN - 0003-9942

IS - 9

ER -