Cognitive neuroscience of sleep

Gina R. Poe, Christine M. Walsh, Theresa E. Bjorness

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Mechanism is at the heart of understanding, and this chapter addresses underlying brain mechanisms and pathways of cognition and the impact of sleep on these processes, especially those serving learning and memory. This chapter reviews the current understanding of the relationship between sleep/waking states and cognition from the perspective afforded by basic neurophysiological investigations. The extensive overlap between sleep mechanisms and the neurophysiology of learning and memory processes provide a foundation for theories of a functional link between the sleep and learning systems. Each of the sleep states, with its attendant alterations in neurophysiology, is associated with facilitation of important functional learning and memory processes. For rapid eye movement (REM) sleep, salient features such as PGO waves, theta synchrony, increased acetylcholine, reduced levels of monoamines and, within the neuron, increased transcription of plasticity-related genes, cumulatively allow for freely occurring bidirectional plasticity, long-term potentiation (LTP) and its reversal, depotentiation. Thus, REM sleep provides a novel neural environment in which the synaptic remodelling essential to learning and cognition can occur, at least within the hippocampal complex. During non-REM sleep Stage 2 spindles, the cessation and subsequent strong bursting of noradrenergic cells and coincident reactivation of hippocampal and cortical targets would also increase synaptic plasticity, allowing targeted bidirectional plasticity in the neocortex as well. In delta non-REM sleep, orderly neuronal reactivation events in phase with slow wave delta activity, together with high protein synthesis levels, would facilitate the events that convert early LTP to long-lasting LTP. Conversely, delta sleep does not activate immediate early genes associated with de novo LTP. This non-REM sleep-unique genetic environment combined with low acetylcholine levels may serve to reduce the strength of cortical circuits that activate in the ~50% of delta-coincident reactivation events that do not appear in their waking firing sequence. The chapter reviews the results of manipulation studies, typically total sleep or REM sleep deprivation, that serve to underscore the functional significance of the phenomenological associations. Finally, the implications of sleep neurophysiology for learning and memory will be considered from a larger perspective in which the association of specific sleep states with both potentiation or depotentiation is integrated into mechanistic models of cognition.

Original languageEnglish (US)
Pages (from-to)1-19
Number of pages19
JournalProgress in Brain Research
Volume185
Issue numberC
DOIs
StatePublished - Jan 1 2010

Fingerprint

Sleep
Long-Term Potentiation
Learning
Cognition
Neurophysiology
REM Sleep
Eye Movements
Long-Term Synaptic Depression
Cognitive Neuroscience
Acetylcholine
Neuronal Plasticity
Immediate-Early Genes
Sleep Deprivation
Sleep Stages
Neocortex
Neurons
Brain

Keywords

  • Acetylcholine (ACh)
  • Bidirectional plasticity
  • Depotentiation
  • Long-term potentiation (LTP)
  • Memory consolidation
  • Norepinephrine (NE)
  • Serotonin (5HT)
  • Slow waves
  • Spike Timing Dependent Plasticity (STDP)
  • Spindles
  • Theta

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cognitive neuroscience of sleep. / Poe, Gina R.; Walsh, Christine M.; Bjorness, Theresa E.

In: Progress in Brain Research, Vol. 185, No. C, 01.01.2010, p. 1-19.

Research output: Contribution to journalArticle

Poe, Gina R. ; Walsh, Christine M. ; Bjorness, Theresa E. / Cognitive neuroscience of sleep. In: Progress in Brain Research. 2010 ; Vol. 185, No. C. pp. 1-19.
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