Cognitive patterns in school-age children with end-stage liver disease.

S. M. Stewart, R. A. Campbell, D. McCallon, D. A. Waller, W. S. Andrews

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Although children with end-stage liver disease (ESLD) have been found to have cognitive delays, the relationship between patterns of cognitive function and diagnostic category, age of onset, duration and severity of disease has not been assessed before transplantation. Verbal and performance IQ (VIQ, PIQ) scores and scores on Bannatyne's cognitive factors for 43 children with ESLD were compared with those of 15 control children with cystic fibrosis (CF) and with existing normative data. Children with biliary atresia had deficits in PIQ, spatial and sequential scores. Children with alpha-1 antitrypsin deficiency did not differ significantly from CF controls but did show deficits compared with normative data. Children with onset of disease in the first year of life had deficits on all cognitive measures compared with both control groups. In contrast, children with later onset differed from the normative population only on VIQ and the acquired knowledge factor. In multiple regression analyses, duration of disease and indexes of liver dysfunction combine to predict cognitive scores. These preliminary findings suggest that children with early onset of liver disease are at high risk for cognitive impairment.

Original languageEnglish (US)
Pages (from-to)331-338
Number of pages8
JournalJournal of Developmental and Behavioral Pediatrics
Volume13
Issue number5
StatePublished - Oct 1992

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End Stage Liver Disease
Cystic Fibrosis
Liver Diseases
alpha 1-Antitrypsin Deficiency
Biliary Atresia
Age of Onset
Cognition
Transplantation
Regression Analysis
Control Groups

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Behavioral Neuroscience
  • Psychology(all)
  • Developmental and Educational Psychology

Cite this

Cognitive patterns in school-age children with end-stage liver disease. / Stewart, S. M.; Campbell, R. A.; McCallon, D.; Waller, D. A.; Andrews, W. S.

In: Journal of Developmental and Behavioral Pediatrics, Vol. 13, No. 5, 10.1992, p. 331-338.

Research output: Contribution to journalArticle

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