Collagen injection as a supplement to arytenoid adduction for vocal fold paralysis

Miwako Kimura, Takaharu Nito, Hiroshi Imagawa, Niro Tayama, Roger W. Chan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: Dysphonia associated with vocal fold paralysis can persist even after successful medialization procedures, including arytenoid adduction. It is hypothesized that laryngeal collagen injection could improve phonation following arytenoid adduction in selected patients. Our objective was to evaluate how collagen injection could result in measurable improvements in vocal function and voice quality. Methods: Forty patients with unilateral vocal fold paralysis who had undergone arytenoid adduction underwent transoral injection of non-cross-linked bovine dermal collagen by means of indirect laryngoscopy and a curved injection device. A control group of 40 patients underwent arytenoid adduction but not collagen injection. The patients' voice quality was assessed perceptually with the GRBAS scale, and vocal function was assessed by acoustic and aerodynamic measures (maximum phonation time and transglottal DC flow). The relative glottal area was also assessed by videostroboscopy. Results: Significant improvements in vocal function and voice quality were observed with collagen injection for those patients who did not achieve satisfactory glottal competence with arytenoid adduction alone. Glottal area measurements revealed that glottic insufficiency was significantly reduced after arytenoid adduction as well as after collagen injection. Conclusions: The findings suggest that collagen injection could be an effective supplementary treatment for improving voice following arytenoid adduction. It has the advantage of being a minimally invasive outpatient office procedure. The long-term efficacy of the procedure should be explored.

Original languageEnglish (US)
Pages (from-to)430-436
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Volume117
Issue number6
StatePublished - Jun 2008

Fingerprint

Vocal Cords
Paralysis
Collagen
Injections
Voice Quality
Phonation
Dysphonia
Laryngoscopy
Tongue
Acoustics
Mental Competency
Outpatients
Equipment and Supplies
Control Groups
Skin

Keywords

  • Augmentation
  • Collagen
  • Laryngeal paralysis
  • Vocal fold medialization

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Collagen injection as a supplement to arytenoid adduction for vocal fold paralysis. / Kimura, Miwako; Nito, Takaharu; Imagawa, Hiroshi; Tayama, Niro; Chan, Roger W.

In: Annals of Otology, Rhinology and Laryngology, Vol. 117, No. 6, 06.2008, p. 430-436.

Research output: Contribution to journalArticle

Kimura, Miwako ; Nito, Takaharu ; Imagawa, Hiroshi ; Tayama, Niro ; Chan, Roger W. / Collagen injection as a supplement to arytenoid adduction for vocal fold paralysis. In: Annals of Otology, Rhinology and Laryngology. 2008 ; Vol. 117, No. 6. pp. 430-436.
@article{7343628b370a4498bb98df5bc97bf28a,
title = "Collagen injection as a supplement to arytenoid adduction for vocal fold paralysis",
abstract = "Objectives: Dysphonia associated with vocal fold paralysis can persist even after successful medialization procedures, including arytenoid adduction. It is hypothesized that laryngeal collagen injection could improve phonation following arytenoid adduction in selected patients. Our objective was to evaluate how collagen injection could result in measurable improvements in vocal function and voice quality. Methods: Forty patients with unilateral vocal fold paralysis who had undergone arytenoid adduction underwent transoral injection of non-cross-linked bovine dermal collagen by means of indirect laryngoscopy and a curved injection device. A control group of 40 patients underwent arytenoid adduction but not collagen injection. The patients' voice quality was assessed perceptually with the GRBAS scale, and vocal function was assessed by acoustic and aerodynamic measures (maximum phonation time and transglottal DC flow). The relative glottal area was also assessed by videostroboscopy. Results: Significant improvements in vocal function and voice quality were observed with collagen injection for those patients who did not achieve satisfactory glottal competence with arytenoid adduction alone. Glottal area measurements revealed that glottic insufficiency was significantly reduced after arytenoid adduction as well as after collagen injection. Conclusions: The findings suggest that collagen injection could be an effective supplementary treatment for improving voice following arytenoid adduction. It has the advantage of being a minimally invasive outpatient office procedure. The long-term efficacy of the procedure should be explored.",
keywords = "Augmentation, Collagen, Laryngeal paralysis, Vocal fold medialization",
author = "Miwako Kimura and Takaharu Nito and Hiroshi Imagawa and Niro Tayama and Chan, {Roger W.}",
year = "2008",
month = "6",
language = "English (US)",
volume = "117",
pages = "430--436",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "6",

}

TY - JOUR

T1 - Collagen injection as a supplement to arytenoid adduction for vocal fold paralysis

AU - Kimura, Miwako

AU - Nito, Takaharu

AU - Imagawa, Hiroshi

AU - Tayama, Niro

AU - Chan, Roger W.

PY - 2008/6

Y1 - 2008/6

N2 - Objectives: Dysphonia associated with vocal fold paralysis can persist even after successful medialization procedures, including arytenoid adduction. It is hypothesized that laryngeal collagen injection could improve phonation following arytenoid adduction in selected patients. Our objective was to evaluate how collagen injection could result in measurable improvements in vocal function and voice quality. Methods: Forty patients with unilateral vocal fold paralysis who had undergone arytenoid adduction underwent transoral injection of non-cross-linked bovine dermal collagen by means of indirect laryngoscopy and a curved injection device. A control group of 40 patients underwent arytenoid adduction but not collagen injection. The patients' voice quality was assessed perceptually with the GRBAS scale, and vocal function was assessed by acoustic and aerodynamic measures (maximum phonation time and transglottal DC flow). The relative glottal area was also assessed by videostroboscopy. Results: Significant improvements in vocal function and voice quality were observed with collagen injection for those patients who did not achieve satisfactory glottal competence with arytenoid adduction alone. Glottal area measurements revealed that glottic insufficiency was significantly reduced after arytenoid adduction as well as after collagen injection. Conclusions: The findings suggest that collagen injection could be an effective supplementary treatment for improving voice following arytenoid adduction. It has the advantage of being a minimally invasive outpatient office procedure. The long-term efficacy of the procedure should be explored.

AB - Objectives: Dysphonia associated with vocal fold paralysis can persist even after successful medialization procedures, including arytenoid adduction. It is hypothesized that laryngeal collagen injection could improve phonation following arytenoid adduction in selected patients. Our objective was to evaluate how collagen injection could result in measurable improvements in vocal function and voice quality. Methods: Forty patients with unilateral vocal fold paralysis who had undergone arytenoid adduction underwent transoral injection of non-cross-linked bovine dermal collagen by means of indirect laryngoscopy and a curved injection device. A control group of 40 patients underwent arytenoid adduction but not collagen injection. The patients' voice quality was assessed perceptually with the GRBAS scale, and vocal function was assessed by acoustic and aerodynamic measures (maximum phonation time and transglottal DC flow). The relative glottal area was also assessed by videostroboscopy. Results: Significant improvements in vocal function and voice quality were observed with collagen injection for those patients who did not achieve satisfactory glottal competence with arytenoid adduction alone. Glottal area measurements revealed that glottic insufficiency was significantly reduced after arytenoid adduction as well as after collagen injection. Conclusions: The findings suggest that collagen injection could be an effective supplementary treatment for improving voice following arytenoid adduction. It has the advantage of being a minimally invasive outpatient office procedure. The long-term efficacy of the procedure should be explored.

KW - Augmentation

KW - Collagen

KW - Laryngeal paralysis

KW - Vocal fold medialization

UR - http://www.scopus.com/inward/record.url?scp=49849089167&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=49849089167&partnerID=8YFLogxK

M3 - Article

C2 - 18646439

AN - SCOPUS:49849089167

VL - 117

SP - 430

EP - 436

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 6

ER -