Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes

Haruta Mogami, Annavarapu Hari Kishore, R. Ann Word

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Preterm premature rupture of membranes (pPROM) is a major cause of preterm birth. Recently, extracellular matrix-directed treatment is applied for wound healing. Here, we used a pregnant mouse model to test the efficacy of collagen type 1 gel for healing of the prematurely ruptured fetal membranes. Although injection of PBS into the ruptured fetal membranes resulted in 40% closure, injection of collagen type 1 improved closure rates to 90% within 72 h. Macrophages of the M2 wound healing phenotype were entrapped in the collagen layer. In primary human amnion mesenchymal cells, collagen type 1 gels activated collagen receptor discoidin domain receptor 2 (DDR2) to induce myosin light chain phosphorylation and migration of injured amnion mesenchymal cells. These findings define the mechanisms for matrix-directed therapeutics for pPROM.

Original languageEnglish (US)
Article number696
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Extraembryonic Membranes
Collagen Type I
Amnion
Wound Healing
Gels
Collagen Receptors
Myosin Light Chains
Injections
Emigration and Immigration
Premature Birth
Extracellular Matrix
Collagen
Macrophages
Phosphorylation
Phenotype
Therapeutics
Preterm Premature Rupture of the Membranes

ASJC Scopus subject areas

  • General

Cite this

Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes. / Mogami, Haruta; Kishore, Annavarapu Hari; Word, R. Ann.

In: Scientific Reports, Vol. 8, No. 1, 696, 01.12.2018.

Research output: Contribution to journalArticle

Mogami, Haruta ; Kishore, Annavarapu Hari ; Word, R. Ann. / Collagen Type 1 Accelerates Healing of Ruptured Fetal Membranes. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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