Collagenolytic Activity in Experimental Herpes Simplex Keratitis

J. P. McCulley; H. H. Slansky; D. Pavan-Langston; C. H. Dohlman

doi:10.1001/archopht.1970.00990040518023

Collagenolytic Activity in Experimental Herpes Simplex Keratitis

J. P. McCulley, H. H. Slansky, D. Pavan-Langston, C. H. Dohlman

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Abstract

Collagenolytic activity was demonstrated in the epithelium of rabbit corneas experimentally infected with herpes simplex virus in 19 of 20 trephined explants. Control epithelial explants demonstrated minimal to no collagenase activity. This finding may offer one explanation for the stromal ulcerations which can occur in herpetic keratitis. Possible mechanisms of this increased enzyme activity are discussed.

Original language	English (US)
Pages (from-to)	516-519
Number of pages	4
Journal	Archives of Ophthalmology
Volume	84
Issue number	4
DOIs	https://doi.org/10.1001/archopht.1970.00990040518023
State	Published - Oct 1970

ASJC Scopus subject areas

Ophthalmology

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10.1001/archopht.1970.00990040518023

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title = "Collagenolytic Activity in Experimental Herpes Simplex Keratitis",

abstract = "Collagenolytic activity was demonstrated in the epithelium of rabbit corneas experimentally infected with herpes simplex virus in 19 of 20 trephined explants. Control epithelial explants demonstrated minimal to no collagenase activity. This finding may offer one explanation for the stromal ulcerations which can occur in herpetic keratitis. Possible mechanisms of this increased enzyme activity are discussed.",

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year = "1970",

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AU - Pavan-Langston, D.

AU - Dohlman, C. H.

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AB - Collagenolytic activity was demonstrated in the epithelium of rabbit corneas experimentally infected with herpes simplex virus in 19 of 20 trephined explants. Control epithelial explants demonstrated minimal to no collagenase activity. This finding may offer one explanation for the stromal ulcerations which can occur in herpetic keratitis. Possible mechanisms of this increased enzyme activity are discussed.

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Collagenolytic Activity in Experimental Herpes Simplex Keratitis

Abstract

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