Collapsing glomerulopathy: a cause of noncardiogenic pulmonary edema.

Michael R. Wiederkehr, Thomas E. Rogers, Orson W. Moe

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Collapsing glomerulopathy is a pathologic diagnosis characterized by obliteration of glomerular capillary lumina, seen most commonly as a primary glomerular disease in young black men. A secondary form with almost identical pathologic features is described in association with human immunodeficiency virus infection. The disease is characterized by heavy proteinuria with variable renal insufficiency at the onset followed by rapid progression to end-stage renal disease with no documented effective therapy. We describe a patient who presented with systemic manifestations, including fever, acute renal failure with massive proteinuria, and noncardiogenic pulmonary edema. Renal biopsy showed classic collapsing glomerulopathy. All known causes of noncardiogenic pulmonary edema were ruled out. The pulmonary syndrome resolved, but the renal disease progressed to end-stage renal disease. We propose consideration of collapsing glomerulopathy in the differential diagnosis of any patient presenting with a multisystem disease including acute renal failure and pulmonary edema.

Original languageEnglish (US)
JournalAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
Volume40
Issue number3
StatePublished - 2002

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Pulmonary Edema
Proteinuria
Acute Kidney Injury
Chronic Kidney Failure
Virus Diseases
Renal Insufficiency
Differential Diagnosis
Fever
HIV
Kidney
Biopsy
Therapeutics

Cite this

Collapsing glomerulopathy : a cause of noncardiogenic pulmonary edema. / Wiederkehr, Michael R.; Rogers, Thomas E.; Moe, Orson W.

In: American journal of kidney diseases : the official journal of the National Kidney Foundation, Vol. 40, No. 3, 2002.

Research output: Contribution to journalArticle

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