Collective activation of MRI agents via encapsulation and disease-triggered release

Mathieu L. Viger, Jagadis Sankaranarayanan, Caroline De Gracia Lux, Minnie Chan, Adah Almutairi

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

An activation mechanism based on encapsulated ultrasmall gadolinium oxide nanoparticles (Gd oxide NPs) in bioresponsive polymer capsules capable of triggered release in response to chemical markers of disease (i.e., acidic pH, H2O2) is presented. Inside the hydrophobic polymeric matrices, the Gd oxide NPs are shielded from the aqueous environment, silencing their ability to enhance water proton relaxation. Upon disassembly of the polymeric particles, activation of multiple contrast agents generates a strong positive contrast enhancement of >1 order of magnitude.

Original languageEnglish (US)
Pages (from-to)7847-7850
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number21
DOIs
StatePublished - May 29 2013

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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