Collective activation of MRI agents via encapsulation and disease-triggered release

Mathieu L. Viger, Jagadis Sankaranarayanan, Caroline De Gracia Lux, Minnie Chan, Adah Almutairi

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

An activation mechanism based on encapsulated ultrasmall gadolinium oxide nanoparticles (Gd oxide NPs) in bioresponsive polymer capsules capable of triggered release in response to chemical markers of disease (i.e., acidic pH, H2O2) is presented. Inside the hydrophobic polymeric matrices, the Gd oxide NPs are shielded from the aqueous environment, silencing their ability to enhance water proton relaxation. Upon disassembly of the polymeric particles, activation of multiple contrast agents generates a strong positive contrast enhancement of >1 order of magnitude.

Original languageEnglish (US)
Pages (from-to)7847-7850
Number of pages4
JournalJournal of the American Chemical Society
Volume135
Issue number21
DOIs
StatePublished - May 29 2013

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Gadolinium
Encapsulation
Nanoparticles
Magnetic resonance imaging
Chemical activation
Oxides
Contrast Media
Capsules
Protons
Polymers
Water
gadolinium oxide

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Collective activation of MRI agents via encapsulation and disease-triggered release. / Viger, Mathieu L.; Sankaranarayanan, Jagadis; De Gracia Lux, Caroline; Chan, Minnie; Almutairi, Adah.

In: Journal of the American Chemical Society, Vol. 135, No. 21, 29.05.2013, p. 7847-7850.

Research output: Contribution to journalArticle

Viger, Mathieu L. ; Sankaranarayanan, Jagadis ; De Gracia Lux, Caroline ; Chan, Minnie ; Almutairi, Adah. / Collective activation of MRI agents via encapsulation and disease-triggered release. In: Journal of the American Chemical Society. 2013 ; Vol. 135, No. 21. pp. 7847-7850.
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