Colloid solution therapy of experimental ischemic intestinal shock in rats

I. Dawidson, J. Ottosson, J. Reisch

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This study evaluated the effects of varying colloid concentrations and infusion volumes on survival and plasma volume expansion in rats subjected to an intestinal ischemic shock. Up to 10% solutions of albumin and dextran-40 in lactated Ringer's solution, infused over a 6-h period, had the same effects on hematocrit (Hct) changes and survival patterns. Mean Hct values (45% to 50%) were independent of colloid solution concentration. With lactated Ringer's solution alone, Hct was 55%, despite the very large volume used; and less than 3% of the infused lactated Ringer's solution remained as plasma volume at 3 and 6 h of infusion. With increasing colloid concentration a greater proportion of the infused volume contributed to plasma volume. Of a 10% colloid solution, 50% and 34% remained as plasma volume at 3 and 6 h. For colloid concentrations between 1% and 3%, there was an equal distribution of infused fluid between the extracellular fluid space and the plasma. Survival rate, as measured by blood volume expansion, was greater with colloid solution concentrations between 2% and 4%.

Original languageEnglish (US)
Pages (from-to)709-714
Number of pages6
JournalCritical Care Medicine
Volume13
Issue number9
StatePublished - 1985

Fingerprint

Investigational Therapies
Colloids
Shock
Plasma Volume
Hematocrit
Extracellular Fluid
Extracellular Space
Dextrans
Blood Volume
Albumins
Ringer's solution
Ringer's lactate

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Colloid solution therapy of experimental ischemic intestinal shock in rats. / Dawidson, I.; Ottosson, J.; Reisch, J.

In: Critical Care Medicine, Vol. 13, No. 9, 1985, p. 709-714.

Research output: Contribution to journalArticle

Dawidson, I. ; Ottosson, J. ; Reisch, J. / Colloid solution therapy of experimental ischemic intestinal shock in rats. In: Critical Care Medicine. 1985 ; Vol. 13, No. 9. pp. 709-714.
@article{06bc9dd4386d4512b017a49b3f01d2b7,
title = "Colloid solution therapy of experimental ischemic intestinal shock in rats",
abstract = "This study evaluated the effects of varying colloid concentrations and infusion volumes on survival and plasma volume expansion in rats subjected to an intestinal ischemic shock. Up to 10{\%} solutions of albumin and dextran-40 in lactated Ringer's solution, infused over a 6-h period, had the same effects on hematocrit (Hct) changes and survival patterns. Mean Hct values (45{\%} to 50{\%}) were independent of colloid solution concentration. With lactated Ringer's solution alone, Hct was 55{\%}, despite the very large volume used; and less than 3{\%} of the infused lactated Ringer's solution remained as plasma volume at 3 and 6 h of infusion. With increasing colloid concentration a greater proportion of the infused volume contributed to plasma volume. Of a 10{\%} colloid solution, 50{\%} and 34{\%} remained as plasma volume at 3 and 6 h. For colloid concentrations between 1{\%} and 3{\%}, there was an equal distribution of infused fluid between the extracellular fluid space and the plasma. Survival rate, as measured by blood volume expansion, was greater with colloid solution concentrations between 2{\%} and 4{\%}.",
author = "I. Dawidson and J. Ottosson and J. Reisch",
year = "1985",
language = "English (US)",
volume = "13",
pages = "709--714",
journal = "Critical Care Medicine",
issn = "0090-3493",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Colloid solution therapy of experimental ischemic intestinal shock in rats

AU - Dawidson, I.

AU - Ottosson, J.

AU - Reisch, J.

PY - 1985

Y1 - 1985

N2 - This study evaluated the effects of varying colloid concentrations and infusion volumes on survival and plasma volume expansion in rats subjected to an intestinal ischemic shock. Up to 10% solutions of albumin and dextran-40 in lactated Ringer's solution, infused over a 6-h period, had the same effects on hematocrit (Hct) changes and survival patterns. Mean Hct values (45% to 50%) were independent of colloid solution concentration. With lactated Ringer's solution alone, Hct was 55%, despite the very large volume used; and less than 3% of the infused lactated Ringer's solution remained as plasma volume at 3 and 6 h of infusion. With increasing colloid concentration a greater proportion of the infused volume contributed to plasma volume. Of a 10% colloid solution, 50% and 34% remained as plasma volume at 3 and 6 h. For colloid concentrations between 1% and 3%, there was an equal distribution of infused fluid between the extracellular fluid space and the plasma. Survival rate, as measured by blood volume expansion, was greater with colloid solution concentrations between 2% and 4%.

AB - This study evaluated the effects of varying colloid concentrations and infusion volumes on survival and plasma volume expansion in rats subjected to an intestinal ischemic shock. Up to 10% solutions of albumin and dextran-40 in lactated Ringer's solution, infused over a 6-h period, had the same effects on hematocrit (Hct) changes and survival patterns. Mean Hct values (45% to 50%) were independent of colloid solution concentration. With lactated Ringer's solution alone, Hct was 55%, despite the very large volume used; and less than 3% of the infused lactated Ringer's solution remained as plasma volume at 3 and 6 h of infusion. With increasing colloid concentration a greater proportion of the infused volume contributed to plasma volume. Of a 10% colloid solution, 50% and 34% remained as plasma volume at 3 and 6 h. For colloid concentrations between 1% and 3%, there was an equal distribution of infused fluid between the extracellular fluid space and the plasma. Survival rate, as measured by blood volume expansion, was greater with colloid solution concentrations between 2% and 4%.

UR - http://www.scopus.com/inward/record.url?scp=0021882347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021882347&partnerID=8YFLogxK

M3 - Article

C2 - 2411470

AN - SCOPUS:0021882347

VL - 13

SP - 709

EP - 714

JO - Critical Care Medicine

JF - Critical Care Medicine

SN - 0090-3493

IS - 9

ER -