Colon Cancer: Inflammation-Associated Cancer

Sherief Shawki, Jean Ashburn, Steven A. Signs, Emina Huang

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Colitis-associated cancer is a relatively rare form of cancer with an unclear pathogenesis. Colitis-associated cancer serves as a prototype of inflammation-associated cancers. Advanced colonoscopic techniques are considered standard of care for surveillance in patients with long-standing colitis, especially those with other risk factors, including sclerosing cholangitis and a family history of colorectal cancer. When colitis-associated cancer is diagnosed, the standard operation involves total proctocolectomy. Restorative procedures and surveillance after colectomy require special considerations. In these contexts, new 3-dimensional human models may be used to usher in personalized medicine.

Original languageEnglish (US)
Pages (from-to)269-287
Number of pages19
JournalSurgical Oncology Clinics of North America
Volume27
Issue number2
DOIs
StatePublished - Apr 2018
Externally publishedYes

Keywords

  • 3D human models
  • Colitis cancer surveillance
  • Colitis-associated cancer
  • Colitis-associated cancer management

ASJC Scopus subject areas

  • Surgery
  • Oncology

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