TY - JOUR
T1 - Colon cancer stem cells
T2 - implications for prevention and therapy
AU - Huang, Emina H.
AU - Wicha, Max S.
N1 - Funding Information:
Sources of financial support: National Institute of Health National Cancer Institute (NCI), K08 CA91915–01A1 (E.H.H.), Comprehensive Cancer Center, Will and Jeanne Caldwell Fund for Cancer Research (E.H.H.), Comprehensive Cancer Center, Weatherwax Foundation (E.H.H.), NCI RO1 CA101860 and RO1 CA129765 (M.S.W.). The authors are grateful to Jain R. Dunckel, Jason Cline and Denise Poirier for preparation of the manuscript.
PY - 2008/11
Y1 - 2008/11
N2 - The recent identification of colon cancer tumor-initiating cells adds further support to the cancer stem cell hypothesis. Ongoing basic and translational research efforts are aimed at gaining an increased understanding of the biology of these cells, as well as methods of targeting them. In addition, the relationship between colon carcinogenesis and inflammatory conditions, such as longstanding colitis and inherited syndromes, might be linked to the effect of the processes on stem cells in the colon. This review summarizes current literature on colon cancer stem cells and proposes strategies aimed at targeting these cells for colon cancer prevention and therapy.
AB - The recent identification of colon cancer tumor-initiating cells adds further support to the cancer stem cell hypothesis. Ongoing basic and translational research efforts are aimed at gaining an increased understanding of the biology of these cells, as well as methods of targeting them. In addition, the relationship between colon carcinogenesis and inflammatory conditions, such as longstanding colitis and inherited syndromes, might be linked to the effect of the processes on stem cells in the colon. This review summarizes current literature on colon cancer stem cells and proposes strategies aimed at targeting these cells for colon cancer prevention and therapy.
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U2 - 10.1016/j.molmed.2008.09.005
DO - 10.1016/j.molmed.2008.09.005
M3 - Review article
C2 - 18929507
AN - SCOPUS:54249087106
SN - 1471-4914
VL - 14
SP - 503
EP - 509
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 11
ER -