Colorectal Cancer in the Young: Does Screening Make Sense?

Research output: Contribution to journalReview article

Abstract

Purpose of Review: Colorectal cancer (CRC) screening is recommended to reduce CRC mortality. This review outlines key factors to consider when recommending screening, including disease burden, screening benefits and harms, and remaining knowledge gaps. Recent Findings: In response to increasing rates of CRC incidence among younger (age < 50 years) adults, the American Cancer Society published guidelines in May 2018 recommending average-risk CRC screening beginning at age 45 (vs. 50) years. Rates of young-onset CRC have increased in the USA since the early 1990s. However, there is very little empirical evidence of screening effectiveness in younger adults, and few studies have reported harms of routine screening in this age group. Further, we know little about the natural history of CRC in younger adults. Summary: Uncertainty surrounding the efficacy of CRC screening in younger adults suggests the benefits may be small. Precision cancer screening—or modified screening regimens based on risk—may improve the balance of screening benefits and harms beyond conventional age-based strategies.

Original languageEnglish (US)
Article number28
JournalCurrent Gastroenterology Reports
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2019

Fingerprint

Colorectal Neoplasms
Early Detection of Cancer
Young Adult
Uncertainty
Age Groups
Guidelines
Mortality
Incidence
Neoplasms

Keywords

  • Clinical guidelines
  • Colorectal neoplasms
  • Early detection of cancer
  • Early-age onset
  • Mass screening

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Colorectal Cancer in the Young : Does Screening Make Sense? / Murphy, Caitlin Claffey.

In: Current Gastroenterology Reports, Vol. 21, No. 7, 28, 01.07.2019.

Research output: Contribution to journalReview article

@article{da67d027ee0f49d7bcc1752184a040f8,
title = "Colorectal Cancer in the Young: Does Screening Make Sense?",
abstract = "Purpose of Review: Colorectal cancer (CRC) screening is recommended to reduce CRC mortality. This review outlines key factors to consider when recommending screening, including disease burden, screening benefits and harms, and remaining knowledge gaps. Recent Findings: In response to increasing rates of CRC incidence among younger (age < 50 years) adults, the American Cancer Society published guidelines in May 2018 recommending average-risk CRC screening beginning at age 45 (vs. 50) years. Rates of young-onset CRC have increased in the USA since the early 1990s. However, there is very little empirical evidence of screening effectiveness in younger adults, and few studies have reported harms of routine screening in this age group. Further, we know little about the natural history of CRC in younger adults. Summary: Uncertainty surrounding the efficacy of CRC screening in younger adults suggests the benefits may be small. Precision cancer screening—or modified screening regimens based on risk—may improve the balance of screening benefits and harms beyond conventional age-based strategies.",
keywords = "Clinical guidelines, Colorectal neoplasms, Early detection of cancer, Early-age onset, Mass screening",
author = "Murphy, {Caitlin Claffey}",
year = "2019",
month = "7",
day = "1",
doi = "10.1007/s11894-019-0695-4",
language = "English (US)",
volume = "21",
journal = "Current Gastroenterology Reports",
issn = "1522-8037",
publisher = "Current Medicine Group",
number = "7",

}

TY - JOUR

T1 - Colorectal Cancer in the Young

T2 - Does Screening Make Sense?

AU - Murphy, Caitlin Claffey

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Purpose of Review: Colorectal cancer (CRC) screening is recommended to reduce CRC mortality. This review outlines key factors to consider when recommending screening, including disease burden, screening benefits and harms, and remaining knowledge gaps. Recent Findings: In response to increasing rates of CRC incidence among younger (age < 50 years) adults, the American Cancer Society published guidelines in May 2018 recommending average-risk CRC screening beginning at age 45 (vs. 50) years. Rates of young-onset CRC have increased in the USA since the early 1990s. However, there is very little empirical evidence of screening effectiveness in younger adults, and few studies have reported harms of routine screening in this age group. Further, we know little about the natural history of CRC in younger adults. Summary: Uncertainty surrounding the efficacy of CRC screening in younger adults suggests the benefits may be small. Precision cancer screening—or modified screening regimens based on risk—may improve the balance of screening benefits and harms beyond conventional age-based strategies.

AB - Purpose of Review: Colorectal cancer (CRC) screening is recommended to reduce CRC mortality. This review outlines key factors to consider when recommending screening, including disease burden, screening benefits and harms, and remaining knowledge gaps. Recent Findings: In response to increasing rates of CRC incidence among younger (age < 50 years) adults, the American Cancer Society published guidelines in May 2018 recommending average-risk CRC screening beginning at age 45 (vs. 50) years. Rates of young-onset CRC have increased in the USA since the early 1990s. However, there is very little empirical evidence of screening effectiveness in younger adults, and few studies have reported harms of routine screening in this age group. Further, we know little about the natural history of CRC in younger adults. Summary: Uncertainty surrounding the efficacy of CRC screening in younger adults suggests the benefits may be small. Precision cancer screening—or modified screening regimens based on risk—may improve the balance of screening benefits and harms beyond conventional age-based strategies.

KW - Clinical guidelines

KW - Colorectal neoplasms

KW - Early detection of cancer

KW - Early-age onset

KW - Mass screening

UR - http://www.scopus.com/inward/record.url?scp=85065887203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065887203&partnerID=8YFLogxK

U2 - 10.1007/s11894-019-0695-4

DO - 10.1007/s11894-019-0695-4

M3 - Review article

C2 - 31098760

AN - SCOPUS:85065887203

VL - 21

JO - Current Gastroenterology Reports

JF - Current Gastroenterology Reports

SN - 1522-8037

IS - 7

M1 - 28

ER -