Comb-type copolymers for controlled DNA delivery

A. Maruyama, A. Ferdous, T. Ishihara, S. Asayama, J. U. Park, M. Nogawa, H. Watanabe, Y. Takei, T. Akaike

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Various comb-type copolymer containing a polycation as a main chain was design to construct delivery systems of DNAs. The comb-type copolymers having cell-specific polysaccharides were proved to be useful to deliver DNA to the target cells in vivo. Of interest, the copolymers with abundant side chains of hydrophilic polymers are capable of stabilizing DNA triplex. Further, injectable nanoparticles for controlled releases of DNAs were fabricated from the copolymer and a biodegradable polymer.

Original languageEnglish (US)
Pages (from-to)1681-1682
Number of pages2
JournalNucleosides and Nucleotides
Volume18
Issue number6-7
StatePublished - 1999

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Comb and Wattles
Copolymers
DNA
Polymers
Nanoparticles
Biodegradable polymers
Polysaccharides
Injections

ASJC Scopus subject areas

  • Biochemistry
  • Genetics

Cite this

Maruyama, A., Ferdous, A., Ishihara, T., Asayama, S., Park, J. U., Nogawa, M., ... Akaike, T. (1999). Comb-type copolymers for controlled DNA delivery. Nucleosides and Nucleotides, 18(6-7), 1681-1682.

Comb-type copolymers for controlled DNA delivery. / Maruyama, A.; Ferdous, A.; Ishihara, T.; Asayama, S.; Park, J. U.; Nogawa, M.; Watanabe, H.; Takei, Y.; Akaike, T.

In: Nucleosides and Nucleotides, Vol. 18, No. 6-7, 1999, p. 1681-1682.

Research output: Contribution to journalArticle

Maruyama, A, Ferdous, A, Ishihara, T, Asayama, S, Park, JU, Nogawa, M, Watanabe, H, Takei, Y & Akaike, T 1999, 'Comb-type copolymers for controlled DNA delivery', Nucleosides and Nucleotides, vol. 18, no. 6-7, pp. 1681-1682.
Maruyama A, Ferdous A, Ishihara T, Asayama S, Park JU, Nogawa M et al. Comb-type copolymers for controlled DNA delivery. Nucleosides and Nucleotides. 1999;18(6-7):1681-1682.
Maruyama, A. ; Ferdous, A. ; Ishihara, T. ; Asayama, S. ; Park, J. U. ; Nogawa, M. ; Watanabe, H. ; Takei, Y. ; Akaike, T. / Comb-type copolymers for controlled DNA delivery. In: Nucleosides and Nucleotides. 1999 ; Vol. 18, No. 6-7. pp. 1681-1682.
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