Combination Immunotherapy Strategies in Breast Cancer

Brie M. Chun, David B. Page, Heather L. McArthur

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Purpose of Review: We summarize combination immunotherapy strategies for the treatment of breast cancer, with a focus on metastatic disease. First, a general overview of combination approaches is presented according to breast cancer subtype. Second, additional review of promising combination approaches is presented. Recent Findings: Combination strategies utilizing chemotherapy or radiotherapy with immune checkpoint inhibition are being evaluated across multiple phase III trials. Dual immunotherapy strategies, such as dual immune checkpoint inhibition or combined co-stimulation/co-inhibition, have supportive preclinical evidence and are under early clinical investigation. Modulation of the immune microenvironment via cytokines and vaccination strategies, as well as locally focused treatments to enhance antigenic responses, are active areas of research. Summary: Pre-clinical and translational research sheds new light on numerous ways the immune system may be modulated to fight against cancer. We describe current and emerging combination approaches which may improve patient outcomes in metastatic breast cancer.

Original languageEnglish (US)
Pages (from-to)228-240
Number of pages13
JournalCurrent Breast Cancer Reports
Volume11
Issue number4
DOIs
StatePublished - Dec 1 2019
Externally publishedYes

Keywords

  • Combination immunotherapy
  • Metastatic breast cancer
  • Treatment

ASJC Scopus subject areas

  • Oncology

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