Combinatorial rules of precursor specification underlying olfactory neuron diversity

Qingyun Li, Tal Soo Ha, Sumie Okuwa, Yiping Wang, Qian Wang, S. Sean Millard, Dean P. Smith, Pelin Cayirlioglu Volkan

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background Sensory neuron diversity ensures optimal detection of the external world and is a hallmark of sensory systems. An extreme example is the olfactory system, as individual olfactory receptor neurons (ORNs) adopt unique sensory identities by typically expressing a single receptor gene from a large genomic repertoire. In Drosophila, about 50 different ORN classes are generated from a field of precursor cells, giving rise to spatially restricted and distinct clusters of ORNs on the olfactory appendages. Developmental strategies spawning ORN diversity from an initially homogeneous population of precursors are largely unknown. Results Here we unravel the nested and binary logic of the combinatorial code that patterns the decision landscape of precursor states underlying ORN diversity in the Drosophila olfactory system. The transcription factor Rotund (Rn) is a critical component of this code that is expressed in a subset of ORN precursors. Addition of Rn to preexisting transcription factors that assign zonal identities to precursors on the antenna subdivides each zone and almost exponentially increases ORN diversity by branching off novel precursor fates from default ones within each zone. In rn mutants, rn-positive ORN classes are converted to rn-negative ones in a zone-specific manner. Conclusions We provide a model describing how nested and binary changes in combinations of transcription factors could coordinate and pattern a large number of distinct precursor identities within a population to modulate the level of ORN diversity during development and evolution.

Original languageEnglish (US)
Pages (from-to)2481-2490
Number of pages10
JournalCurrent Biology
Volume23
Issue number24
DOIs
StatePublished - Dec 16 2013

Fingerprint

Olfactory Receptor Neurons
Odorant Receptors
olfactory receptors
Neurons
neurons
Specifications
Transcription Factors
transcription factors
Drosophila
sensory system
sensory neurons
Sensory Receptor Cells
appendages
antennae
Population
branching
spawning
Genes
genomics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Li, Q., Ha, T. S., Okuwa, S., Wang, Y., Wang, Q., Millard, S. S., ... Volkan, P. C. (2013). Combinatorial rules of precursor specification underlying olfactory neuron diversity. Current Biology, 23(24), 2481-2490. https://doi.org/10.1016/j.cub.2013.10.053

Combinatorial rules of precursor specification underlying olfactory neuron diversity. / Li, Qingyun; Ha, Tal Soo; Okuwa, Sumie; Wang, Yiping; Wang, Qian; Millard, S. Sean; Smith, Dean P.; Volkan, Pelin Cayirlioglu.

In: Current Biology, Vol. 23, No. 24, 16.12.2013, p. 2481-2490.

Research output: Contribution to journalArticle

Li, Q, Ha, TS, Okuwa, S, Wang, Y, Wang, Q, Millard, SS, Smith, DP & Volkan, PC 2013, 'Combinatorial rules of precursor specification underlying olfactory neuron diversity', Current Biology, vol. 23, no. 24, pp. 2481-2490. https://doi.org/10.1016/j.cub.2013.10.053
Li, Qingyun ; Ha, Tal Soo ; Okuwa, Sumie ; Wang, Yiping ; Wang, Qian ; Millard, S. Sean ; Smith, Dean P. ; Volkan, Pelin Cayirlioglu. / Combinatorial rules of precursor specification underlying olfactory neuron diversity. In: Current Biology. 2013 ; Vol. 23, No. 24. pp. 2481-2490.
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