Combined fludarabine and rituximab for low grade lymphoma and chronic lymphocytic leukemia

David G. Savage, Neil S. Cohen, Charles S. Hesdorffer, Daniel Heitjan, Martin W. Oster, Thomas J. Garrett, Michael Bar, Salvatore Del Prete, Robert March, Mathew Lonberg, Susan Talbot, J. Gregory Mears, Michael Flamm, Robert N. Taub, Gwen Nichols

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

As both fludarabine and rituximab are active against indolent lymphoproliferative disorders, we have studied the combination of fludarabine and rituximab in patients with low-grade lymphoma and chronic lymphocytic leukemia (CLL) in phase I/II fashion. Of 33 patients enrolled, 21(63.6%) had low-grade lymphoma and 12 (36.4%) had CLL. They received fludarabine 30 mg/m2 on days 1-4 and rituximab 125, 250 or 375 mg/m2 on day 5 at intervals of 28 days to a maximum of 8 cycles. Three patients were removed from the study because of rituximab-associated anaphylaxis and four because of prolonged hematopoietic toxicity. Toxicity and responsiveness did not differ at the different dose levels of rituximab. For 29 evaluable patients, responses were seen in 82.8% and complete responses in 34.5%. Of 7 responding patients not referred for stem cell transplantation, 6 remain in complete remission at a median follow-up of 16 months (range 4-30 months). Of 13 previously untreated patients, all responded and 46.2% had a complete response. Of 16 previously treated patients, 68.5% responded and 25% had a complete response. The combination of fludarabine and rituximab has major activity and acceptable toxicity in patients with low-grade lymphoma and CLL.

Original languageEnglish (US)
Pages (from-to)477-481
Number of pages5
JournalLeukemia and Lymphoma
Volume44
Issue number3
DOIs
StatePublished - Mar 1 2003

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Keywords

  • Chronic lymphocytic leukemia
  • Fludarabine
  • Lymphoma
  • Rituximab

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Savage, D. G., Cohen, N. S., Hesdorffer, C. S., Heitjan, D., Oster, M. W., Garrett, T. J., Bar, M., Del Prete, S., March, R., Lonberg, M., Talbot, S., Mears, J. G., Flamm, M., Taub, R. N., & Nichols, G. (2003). Combined fludarabine and rituximab for low grade lymphoma and chronic lymphocytic leukemia. Leukemia and Lymphoma, 44(3), 477-481. https://doi.org/10.1080/1042819021000046958