Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus

Kendra A. Young, Melissa E. Munroe, Joel M. Guthridge, Diane L. Kamen, Timothy B. Niewold, Gary S. Gilkeson, Michael H. Weisman, Mariko L. Ishimori, Jennifer Kelly, Patrick M. Gaffney, Kathy H. Sivils, Rufei Lu, Daniel J. Wallace, David R. Karp, John B. Harley, Judith A. James, Jill M. Norris

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Objective We examined whether measures of vitamin D were associated with transitioning to systemic lupus erythematosus (SLE) in individuals at risk for SLE. Methods 436 individuals who reported having a relative with SLE but who did not have SLE themselves were evaluated at baseline and again an average of 6.3 (±3.9) years later. Fifty-six individuals transitioned to SLE (=4 cumulative American College of Rheumatology criteria). 25-Hydroxyvitamin D (25[OH]D) levels were measured by ELISA. Six single-nucleotide polymorphisms in four vitamin D genes were genotyped. Generalised estimating equations, adjusting for correlation within families, were used to test associations between the vitamin D variables and the outcome of transitioning to SLE. Results Mean baseline 25[OH]D levels (p=0.42) and vitamin D supplementation (p=0.65) were not different between those who did and did not transition to SLE. Vitamin D deficiency (25[OH]D

Original languageEnglish (US)
JournalAnnals of the Rheumatic Diseases
DOIs
StateAccepted/In press - Jun 9 2016

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

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    Young, K. A., Munroe, M. E., Guthridge, J. M., Kamen, D. L., Niewold, T. B., Gilkeson, G. S., Weisman, M. H., Ishimori, M. L., Kelly, J., Gaffney, P. M., Sivils, K. H., Lu, R., Wallace, D. J., Karp, D. R., Harley, J. B., James, J. A., & Norris, J. M. (Accepted/In press). Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2016-209157