COMMD proteins

COMMing to the scene

G. N. Maine, E. Burstein

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

COMM Domain-containing or COMMD proteins are a recently discovered group of factors defined by the presence of a unique motif in their extreme carboxy termini (Copper metabolism MURR1, or COMM domain). This protein family is comprised of ten members which are widely conserved throughout evolution and share certain functional properties. At the present time, a number of seemingly discrete functions have been ascribed to these factors. These include the regulation of such events as the activity of the transcription factor NF-κB, copper homeostasis, the function of the epithelial sodium channel, and cell proliferation. A unifying mechanism that would explain all these events is lacking at the moment, but recent studies suggest that regulation of the ubiquitin pathway may be the basis of many of the functions of the COMMD protein family.

Original languageEnglish (US)
Pages (from-to)1997-2005
Number of pages9
JournalCellular and Molecular Life Sciences
Volume64
Issue number15
DOIs
StatePublished - Aug 2007

Fingerprint

Copper
Epithelial Sodium Channels
Proteins
Cell proliferation
Ubiquitin
Metabolism
Homeostasis
Transcription Factors
Cell Proliferation

Keywords

  • Calcium
  • COMMD protein
  • COMMD1
  • Copper
  • Cullin
  • ENaC
  • HCaRG
  • MURR1
  • NF-κB
  • Ubiquitin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

COMMD proteins : COMMing to the scene. / Maine, G. N.; Burstein, E.

In: Cellular and Molecular Life Sciences, Vol. 64, No. 15, 08.2007, p. 1997-2005.

Research output: Contribution to journalArticle

Maine, G. N. ; Burstein, E. / COMMD proteins : COMMing to the scene. In: Cellular and Molecular Life Sciences. 2007 ; Vol. 64, No. 15. pp. 1997-2005.
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