Commensal bacteria protect against food allergen sensitization

Andrew T. Stefka, Taylor Feehley, Prabhanshu Tripathi, Ju Qiu, Kathy McCoy, Sarkis K. Mazmanian, Melissa Y. Tjota, Goo Young Seo, Severine Cao, Betty R. Theriault, Dionysios A. Antonopoulos, Liang Zhou, Eugene B. Chang, Yang Xin Fu, Cathryn R. Nagler

Research output: Contribution to journalArticle

361 Scopus citations

Abstract

Environmentally induced alterations in the commensal microbiota have been implicated in the increasing prevalence of food allergy. We show here that sensitization to a food allergen is increased in mice that have been treated with antibiotics or are devoid of a commensal microbiota. By selectively colonizing gnotobiotic mice, we demonstrate that the allergy-protective capacity is conferred by a Clostridia-containing microbiota. Microarray analysis of intestinal epithelial cells from gnotobiotic mice revealed a previously unidentified mechanism by which Clostridia regulate innate lymphoid cell function and intestinal epithelial permeability to protect against allergen sensitization. Our findings will inform the development of novel approaches to prevent or treat food allergy based on modulating the composition of the intestinal microbiota.

Original languageEnglish (US)
Pages (from-to)13145-13150
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number36
DOIs
StatePublished - 2014

Keywords

  • Barrier
  • IL-22
  • Microbiome

ASJC Scopus subject areas

  • General

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    Stefka, A. T., Feehley, T., Tripathi, P., Qiu, J., McCoy, K., Mazmanian, S. K., Tjota, M. Y., Seo, G. Y., Cao, S., Theriault, B. R., Antonopoulos, D. A., Zhou, L., Chang, E. B., Fu, Y. X., & Nagler, C. R. (2014). Commensal bacteria protect against food allergen sensitization. Proceedings of the National Academy of Sciences of the United States of America, 111(36), 13145-13150. https://doi.org/10.1073/pnas.1412008111